- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TLE1 Antibody / Transducin-Like Enhancer Protein 1 [clone TLE1/2946R] (V7357)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7357-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V7357-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7357SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | TLE1/2946R |
| Purity | Protein A affinity chromatography |
| UniProt | Q04724 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This TLE1 antibody is available for research use only. |
|
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Transducin-Like Enhancer Protein 1 (TLE1) is a nuclear transcriptional corepressor encoded by the human TLE1 gene and is a member of the Groucho/TLE family of transcriptional regulatory proteins that control gene expression during development and cellular differentiation. TLE1 Antibody / Transducin-Like Enhancer Protein 1 (clone TLE1/2946R) targets this widely studied Transducin-Like Enhancer Protein 1 protein, a transcriptional repression scaffold that integrates signaling inputs from multiple developmental pathways. Transducin-Like Enhancer Protein 1 functions as a central regulatory component of transcriptional repression complexes that influence cell fate determination, embryonic patterning, and lineage specification.
TLE1 antibody, also referred to as Transducin-like enhancer protein 1 antibody or Transducin-like enhancer of split 1 antibody in the literature, recognizes a transcriptional regulator belonging to the conserved Groucho family of transcriptional corepressors. Transducin-Like Enhancer Protein 1 does not bind DNA directly but instead associates with DNA-binding transcription factors to suppress transcription of target genes. Through interactions with chromatin remodeling machinery and histone deacetylase complexes, Transducin-Like Enhancer Protein 1 promotes chromatin condensation and transcriptional silencing across multiple signaling networks that regulate developmental gene expression programs.
Structurally, Transducin-Like Enhancer Protein 1 contains an N-terminal glutamine-rich region that promotes oligomerization of transcriptional repression complexes and a C-terminal WD repeat domain that mediates protein-protein interactions with transcription factors and regulatory proteins. These WD repeat motifs enable Transducin-Like Enhancer Protein 1 to assemble large multiprotein repression complexes that regulate transcription factor activity and coordinate gene expression programs involved in cellular differentiation and tissue development.
Transducin-Like Enhancer Protein 1 participates in several major signaling pathways including Notch signaling and Wnt signaling, where it functions as a transcriptional corepressor downstream of pathway activation. In these pathways, Transducin-Like Enhancer Protein 1 interacts with transcription factor complexes to regulate genes controlling proliferation, differentiation, and developmental patterning. Because these signaling pathways are fundamental regulators of cell fate decisions, Transducin-Like Enhancer Protein 1 plays an important role in maintaining transcriptional balance during tissue development and cellular homeostasis.
In addition to its developmental roles, Transducin-Like Enhancer Protein 1 has been widely studied in cancer biology because altered expression of TLE1 can occur in certain tumor types. Numerous molecular pathology studies have examined Transducin-Like Enhancer Protein 1 expression patterns in tumors, reflecting the importance of this transcriptional corepressor in gene regulatory networks that influence tumor cell differentiation and transcriptional control mechanisms.
A recombinant rabbit monoclonal clone TLE1/2946R antibody targets Transducin-Like Enhancer Protein 1 and enables detection of TLE1 protein expression in research applications investigating transcriptional repression complexes, developmental signaling pathways, and regulatory gene expression networks controlled by the Groucho/TLE family of transcriptional corepressors.
Optimal dilution of the TLE1 Antibody / Transducin-Like Enhancer Protein 1 should be determined by the researcher.
A portion of amino acids 175-338 from the human protein was used as the immunogen for the TLE1/Transducin-Like Enhancer Protein 1 antibody.
Store the recombinant TLE1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
TLE1 antibody, Transducin-like enhancer protein 1 antibody, Transducin-like enhancer of split 1 antibody, Groucho-related protein TLE1 antibody, Groucho homolog TLE1 antibody, TLE transcriptional corepressor antibody
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