- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Thyroglobulin Antibody / TG [clone rTGB/4744] (V8717)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8717-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8717-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V8717SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rTGB/4744 |
| Purity | Protein G affinity chromatography |
| UniProt | P01266 |
| Localization | Cytoplasmic, secreted |
| Applications | Flow Cytometry : 0.5-1ug/million cells Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Thyroglobulin antibody is available for research use only. |
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Thyroglobulin antibody recognizes Thyroglobulin, a large glycoprotein encoded by the TG gene that is synthesized and secreted by thyroid follicular epithelial cells. Thyroglobulin is the precursor protein required for thyroid hormone biosynthesis and is stored in the colloid of thyroid follicles. It serves as the scaffold for iodination and coupling reactions that generate thyroxine and triiodothyronine, making it essential for endocrine regulation of metabolism.
Thyroglobulin is synthesized in the rough endoplasmic reticulum, undergoes glycosylation and dimerization in the Golgi apparatus, and is secreted into the follicular lumen where it becomes iodinated. Following stimulation by thyroid stimulating hormone, iodinated Thyroglobulin is endocytosed and proteolytically processed to release active thyroid hormones. Because of its role in hormone production, Thyroglobulin is highly expressed in normal thyroid tissue and differentiated thyroid epithelium.
Clinically, Thyroglobulin expression is widely studied in thyroid carcinoma research. It is commonly retained in differentiated thyroid cancers such as papillary and follicular carcinoma, while reduced or absent expression may be observed in poorly differentiated or anaplastic tumors. For this reason, Thyroglobulin antibody is frequently used in research settings to evaluate thyroid lineage differentiation and to study tumor biology in endocrine malignancies.
Thyroglobulin is primarily localized to the cytoplasm of thyroid follicular cells and is abundantly present in the follicular lumen as colloid material. Because of its tissue-restricted expression pattern, Thyroglobulin antibody serves as a reliable marker of thyroid epithelial origin in research applications. A Thyroglobulin antibody can be used to detect TG protein expression in studies focused on thyroid development, endocrine signaling, and thyroid tumor biology.
Optimal dilution of the Thyroglobulin antibody should be determined by the researcher.
Human thyroid follicular cells were used as the immunogen for the Thyroglobulin antibody.
Store the Thyroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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