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Home >> Antibodies >> Recombinant Thymidine Phosphorylase Antibody / PD-ECGF

Recombinant Thymidine Phosphorylase Antibody / PD-ECGF [clone TYMP/2890R] (V3978)

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  Catalog No Formulation Size Price (USD)  
Image V3978-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3978-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3978SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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Western blot testing of human spleen tissue with recombinant Thymidine Phosphorylase antibody. Predicted molecular weight ~55 kDa.
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Western blot testing of human spleen tissue with recombinant Thymidine Phosphorylase antibody. Predicted molecular weight ~55 kDa.
SDS-PAGE analysis of purified, BSA-free recombinant Thymidine Phosphorylase antibody (clone TYMP/2890R) as confirmation of integrity and purity.
IHC staining of FFPE human prostate carcimoma with recombinant Thymidine Phosphorylase antibody (clone TYMP/2890R). Required HIER: requires boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min and allow to cool before testing.
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name TYMP/2890R
Purity Protein A affinity chromatography
UniProt P19971
Localization Cytoplasmic, nuclear
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Western blot : 1-2ug/ml
Limitations This recombinant Thymidine Phosphorylase antibody is available for research use only.
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Description

Recognizes a 485 amino acid protein (55 kDa monomer / 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant Thymidine Phosphorylase antibody to be titered up or down for optimal performance.

Immunogen

Human recombinant full length protein was used as the immunogen for this recombinant Thymidine Phosphorylase antibody.

Storage

Store the recombinant Thymidine Phosphorylase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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