- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TDP43 Antibody Rabbit Monoclonal / TARDBP / TAR DNA binding protein [clone TARDP/9299R] (V5595)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5595-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5595-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5595SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | TARDP/9299R |
| Purity | Protein A/G affinity |
| UniProt | Q13148 |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant TDP43 antibody is available for research use only. |
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TDP43 antibody recognizes TAR DNA binding protein 43, also known as TARDBP, a ubiquitously expressed nuclear RNA- and DNA-binding protein encoded by the TARDBP gene. TDP-43 is predominantly localized to the nucleus under physiological conditions, where it regulates transcription, alternative splicing, RNA stability, and microRNA processing. TDP43 Antibody Rabbit Monoclonal is developed to detect endogenous TAR DNA binding protein 43 in research applications focused on RNA metabolism and neurodegenerative disease mechanisms.
TAR DNA binding protein 43 contains two RNA recognition motifs that bind UG-rich RNA sequences and a C-terminal glycine-rich domain that mediates protein-protein interactions. Through these domains, TARDBP controls processing and transport of numerous transcripts involved in neuronal development, synaptic function, and cellular stress responses. TDP-43 continuously shuttles between the nucleus and cytoplasm and participates in stress granule dynamics during cellular stress.
The TARDBP gene is located on chromosome 1p36.22 and produces multiple isoforms through alternative splicing. Under pathological conditions, TDP-43 undergoes cytoplasmic redistribution, hyperphosphorylation, ubiquitination, and proteolytic cleavage, generating C-terminal fragments that accumulate in inclusions. Aggregated TDP-43 is a defining pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Loss of normal nuclear TARDBP function combined with toxic cytoplasmic aggregation is believed to contribute to neuronal dysfunction and degeneration.
Beyond neurodegeneration, TARDBP has been implicated in cancer biology, inflammation, and viral replication due to its broad regulatory role in gene expression. Altered expression or localization of TDP-43 may influence apoptosis pathways, cell cycle progression, and RNA regulatory networks across diverse tissue types.
Clone TARDP/9299R is a rabbit monoclonal antibody that recognizes TAR DNA binding protein 43 and supports studies of nuclear RNA regulation, cytoplasmic aggregation, and TDP-43-associated disease pathology.
Optimal dilution of the recombinant TDP43 antibody should be determined by the researcher.
A recombinant fragment within human TDP43 aa 200 to the C-terminus was used as the immunogen for the recombinant TDP43 antibody.
Aliquot the recombinant TDP43 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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