- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Synaptophysin Antibody Recombinant Rabbit MAb Clone SYP/4503R / Synaptophysin (SYP) Antibody [clone SYP/4503R] (V8643)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8643-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8643-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8643SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | SYP/4503R |
| Purity | Protein A affinity chromatography |
| UniProt | IDP08247 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant Synaptophysin antibody is available for research use only. |
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Synaptophysin (SYP) is an integral synaptic vesicle membrane glycoprotein that is highly enriched in presynaptic terminals of neurons and in neuroendocrine secretory vesicles. Synaptophysin Antibody Recombinant Rabbit MAb Clone SYP/4503R is used to detect SYP protein in studies of neuronal synapses and synaptic vesicle biology, where Synaptophysin serves as one of the most widely recognized molecular markers of presynaptic vesicle membranes. Because synaptic vesicles are abundant in neuronal tissue, detection of SYP supports investigation of synaptic vesicle organization and neuronal signaling pathways.
Synaptophysin is also referred to in the literature as synaptic vesicle glycoprotein p38 or major synaptic vesicle protein p38 and is encoded by the SYP gene. The protein contains four transmembrane domains that anchor it within the lipid bilayer of synaptic vesicles. Through these structural features, Synaptophysin participates in vesicle trafficking, vesicle recycling, and neurotransmitter release at neuronal synapses. The protein interacts with vesicle-associated proteins involved in exocytosis and membrane fusion, helping regulate synaptic vesicle cycling within presynaptic terminals.
Within neurons, Synaptophysin localizes primarily to presynaptic boutons along axons where clusters of synaptic vesicles accumulate prior to neurotransmitter release. Because of this localization, Synaptophysin is widely used as a biochemical marker of synaptic vesicle abundance and neuronal synapse density. Detection of SYP allows researchers to study the distribution of presynaptic vesicle proteins and to evaluate neuronal connectivity in experimental models of brain function and neurological disease.
Clone SYP/4503R is a recombinant rabbit monoclonal antibody developed to recognize Synaptophysin protein. Recombinant rabbit monoclonal antibodies provide consistent target recognition and are frequently used for detection of vesicle-associated proteins in neuronal and neuroendocrine samples. Clone SYP/4503R recognizes the Synaptophysin protein present in synaptic vesicle membranes and supports investigation of synaptic vesicle protein expression in neuroscience research.
Synaptophysin expression is abundant throughout the central nervous system including the cerebral cortex, hippocampus, cerebellum, and spinal cord. The protein is also present in neuroendocrine cells such as pancreatic islet cells, adrenal medulla chromaffin cells, and endocrine cells of the gastrointestinal tract. Because of this distribution, SYP serves as a widely used marker for neuronal lineage cells and neuroendocrine differentiation in biological research.
Due to its strong association with synaptic vesicle membranes and presynaptic compartments, Synaptophysin remains one of the most widely used markers for studying synaptic vesicle biology and neuronal communication. Detection of SYP using clone SYP/4503R supports research into synaptic vesicle trafficking, neuronal signaling mechanisms, and synapse-associated changes in neurological disease models.
Optimal dilution of the Synaptophysin Antibody Recombinant Rabbit MAb Clone SYP/4503R should be determined by the researcher.
A portion of amino acids 224-313 from the human protein was used as the immunogen for the Synaptophysin Antibody Recombinant Rabbit MAb Clone SYP/4503R.
Store the recombinant Synaptophysin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
SYP antibody, Synaptic vesicle glycoprotein antibody, Major synaptic vesicle protein p38 antibody, Synaptophysin p38 antibody
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