- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Synaptophysin Antibody [clone SYP/4503R] (V8643)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8643-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8643-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V8643SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | SYP/4503R |
| Purity | Protein A affinity chromatography |
| UniProt | IDP08247 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant Synaptophysin antibody is available for research use only. |
|
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Recombinant Synaptophysin antibody detects synaptophysin, a synaptic vesicle glycoprotein encoded by the SYP gene. Synaptophysin is one of the most abundant proteins in presynaptic vesicles, where it regulates exocytosis and neurotransmitter release. Because it is expressed across nearly all types of neurons, Recombinant Synaptophysin antibody is an essential reagent in neuroscience, pathology, and developmental biology.
Synaptophysin is a 38 kDa integral membrane protein with four transmembrane domains and a short cytoplasmic tail. It contributes to vesicle biogenesis and recycling, ensuring efficient neurotransmitter release. Synaptophysin is widely used as a marker of presynaptic terminals, providing insights into synaptic density and connectivity. In pathology, synaptophysin expression is used to identify neuroendocrine tumors and assess synaptic integrity in neurodegenerative diseases.
The Recombinant Synaptophysin antibody clone SYP/4503R provides specific and reproducible recognition. Recombinant production ensures lot-to-lot consistency, minimizing variability in long-term studies. Clone SYP/4503R has been cited in peer-reviewed publications investigating neurodegeneration, synaptic plasticity, and tumor classification. Its applications include immunohistochemistry, Western blotting, and immunofluorescence.
Research using clone SYP/4503R has demonstrated that synaptophysin serves as a robust marker of synapse density, useful for quantifying changes in disorders such as Alzheimerâs and Parkinsonâs disease. In oncology, synaptophysin detection supports diagnosis of neuroendocrine tumors, including pheochromocytomas and small cell lung carcinoma. Beyond pathology, this antibody enables developmental studies of synapse formation and neural circuit assembly.
NSJ Bioreagents supplies this Recombinant Synaptophysin antibody to support neuroscience, oncology, and developmental biology. Alternate designations include SYP antibody, synaptic vesicle protein antibody, major synaptic vesicle glycoprotein antibody, neuroendocrine tumor marker antibody, and synapse density marker antibody.
Optimal dilution of the recombinant Synaptophysin antibody should be determined by the researcher.
A portion of amino acids 224-313 from the human protein was used as the immunogen for the recombinant Synaptophysin antibody.
Store the recombinant Synaptophysin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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