- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Stathmin 1 Antibody rSTMN1/9255 / STMN1 Recombinant Monoclonal Antibody [clone rSTMN1/9255] (V5504)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5504-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5504-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5504SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rSTMN1/9255 |
| Purity | Protein A/G affinity |
| UniProt | P16949 |
| Localization | Cytoplasm, Cytoskeleton |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Stathmin 1 Antibody rSTMN1/9255 / STMN1 Recombinant Monoclonal Antibody is available for research use only. |
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Stathmin 1 Antibody rSTMN1/9255 / STMN1 Recombinant Monoclonal Antibody recognizes stathmin 1, a cytoplasmic phosphoprotein encoded by the STMN1 gene. Also known as oncoprotein 18, OP18, and metablastin, stathmin 1 regulates microtubule dynamics by interacting with soluble tubulin and influencing microtubule assembly. Its activity contributes to cytoskeletal organization, cell division, migration, and the maintenance of cellular architecture. Stathmin belongs to a family of proteins that regulate microtubule behavior in response to intracellular signaling.
Stathmin 1 contains a tubulin-interacting domain that allows it to bind soluble alpha/beta-tubulin heterodimers. This interaction can limit the availability of tubulin for microtubule polymerization and influence microtubule stability. The protein also promotes microtubule destabilization through mechanisms associated with microtubule dynamics. These activities are regulated by phosphorylation, allowing stathmin to respond to changes in cellular signaling and cytoskeletal requirements.
Several serine residues, including Ser16, Ser25, Ser38, and Ser63, serve as regulatory phosphorylation sites. Phosphorylation generally reduces the ability of stathmin to destabilize microtubules, supporting the controlled assembly of microtubule networks during cell cycle progression. Multiple protein kinases participate in this regulation, linking stathmin activity to pathways associated with growth factor responses, mitotic entry, and cellular differentiation. The balance between phosphorylated and unphosphorylated stathmin influences its interactions with tubulin and its effects on microtubule organization.
During mitosis, microtubules reorganize into the spindle apparatus responsible for chromosome segregation. Stathmin 1 contributes to the regulation of this process and has also been implicated in cellular migration, where dynamic microtubule remodeling supports changes in cell shape and movement. Altered STMN1 expression has been reported in several cancers, including breast, lung, colorectal, and liver malignancies. Research has investigated associations between stathmin expression, proliferative activity, invasive behavior, and responses to microtubule-targeting therapies.
Stathmin 1 is therefore an important component of the signaling networks that coordinate cytoskeletal dynamics with cellular proliferation and movement. NSJ Bioreagents offers this Stathmin 1 Antibody for investigating microtubule regulation, mitotic progression, and the relationship between intracellular signaling and cytoskeletal organization.
Explore our STMN1 Antibody R31986 for additional research tools targeting stathmin 1, with validation data spanning Western blot, immunohistochemistry, immunofluorescence, and flow cytometry.
Optimal dilution of the Stathmin 1 Antibody rSTMN1/9255 / STMN1 Recombinant Monoclonal Antibody should be determined by the researcher.
A recombinant fragment (within amino acids 1-148) of human STMN1 protein was used as the immunogen for the Stathmin 1 Antibody rSTMN1/9255.
Aliquot the Stathmin 1 Antibody rSTMN1/9255 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STMN1 antibody, Oncoprotein 18 antibody, OP18 antibody, Metablastin antibody, Leukemia-associated phosphoprotein p18 antibody
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