• Tel: 858.663.9055
  • SeparatorEmail: info@nsjbio.com
  • Tel: 858.663.9055
  • Email: info@nsjbio.com
Home >> Antibodies >> Recombinant STAT6 Antibody

Recombinant STAT6 Antibody [clone STAT6/7163R] (V4052)

NSJ bio Image Pdf Image
  Catalog No Formulation Size Price (USD)  
Image V4052-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
Image
V4052-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
Image
V4052SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recrabbitmono
Bulk quote request
›
Immunohistochemistry analysis of STAT6 antibody in human renal cell carcinoma tissue (clone STAT6/7163R). FFPE human renal cell carcinoma sections demonstrate strong HRP-DAB brown nuclear staining in tumor epithelial cells forming papillary and glandular structures. The predominant nuclear localization is consistent with activated Signal transducer and activator of transcription 6, reflecting cytokine-driven phosphorylation and nuclear translocation. Cytoplasmic staining can be seen, and surrounding stromal elements show limited background signal. Heat induced epitope retrieval was performed by boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 20 minutes followed by cooling prior to antibody incubation.
IHC staining of FFPE human liposarcoma tissue with recombinant STAT6 antibody (clone STAT6/7163R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human cerebellum tissue with recombinant STAT6 antibody (clone STAT6/7163R). Negative control inset: PBS used instead of primary antibody to control for secondary Ab binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Rabbit
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name STAT6/7163R
Purity Protein A/G affinity
UniProt P42226
Localization Cytoplasm, nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant STAT6 antibody is available for research use only.
Review this product on BioCompare and get a $20 Amazon gift card

Related Products

Description

STAT6 antibody recognizes Signal Transducer and Activator of Transcription 6, a cytokine-activated transcription factor that mediates interleukin-4 and interleukin-13 signaling. Encoded by the STAT6 gene on chromosome 12q13.3, this protein functions as a critical regulator of type 2 immune responses. In unstimulated cells, STAT6 resides predominantly in the cytoplasm. Upon cytokine engagement, it undergoes phosphorylation, dimerization, and nuclear translocation to regulate gene expression.

Signal Transducer and Activator of Transcription 6 is essential for Th2 lineage commitment and B cell immunoglobulin class switching. Activation through IL-4 receptor complexes results in recruitment of STAT6 to phosphorylated receptor chains via its SH2 domain. Once phosphorylated, STAT6 dimers bind promoter regions of target genes involved in allergic inflammation, including those regulating IgE production, chemokine expression, and epithelial barrier responses.

STAT6 contains conserved domains typical of STAT proteins, including an N-terminal oligomerization domain, coiled-coil region, DNA-binding domain, linker, SH2 domain, and transactivation domain. These domains enable STAT6 to function as both a signal transducer and a transcriptional regulator. Through these structural features, STAT6 participates in coordinated immune responses and tissue remodeling processes.

Expression of STAT6 is observed in immune cell populations such as T lymphocytes, B lymphocytes, and macrophages, as well as in certain epithelial and stromal cells following cytokine stimulation. Dysregulated STAT6 activity has been associated with allergic disease, asthma pathogenesis, and select tumor types. In research models of soft tissue tumors, nuclear localization of STAT6 has been studied as a molecular feature linked to specific gene fusions and signaling alterations.

Application Notes

Optimal dilution of the recombinant STAT6 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the recombinant STAT6 antibody.

Storage

Aliquot the recombinant STAT6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Related Products

   1.   View all STAT6 antibodies

Cross
Bulk Quote Request Form
Name*:
Organization*:
Email*:
Phone Number*:
Catalog No.*:
Comments and Specifics(amount, formulation, etc.)*:
Validation code: Captchapackage Image


Can't read the image? click here to refresh.
    *required field

Your bulk quote request has been submitted successfully!

Please contact us if you have any questions.