- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
StAR Antibody Recombinant Rabbit MAb STAR/3915R / Steroidogenic acute regulatory protein [clone STAR/3915R] (V8972)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8972-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V8972-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8972SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | STAR/3915R |
| Purity | Protein A/G affinity |
| UniProt | P49675 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant StAR antibody is available for research use only. |
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Steroidogenic Acute Regulatory Protein (StAR), encoded by the STARD1 gene, is a mitochondrial cholesterol transport protein that plays a central role in steroid hormone biosynthesis within endocrine tissues. StAR Antibody Recombinant Rabbit MAb STAR/3915R targets this steroidogenic regulatory protein and supports research examining steroid hormone production and endocrine cell biology. StAR mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, a process that represents the rate-limiting step in steroidogenesis. Because this function occurs specifically in steroid-producing cells, StAR is widely studied as a marker of steroidogenic activity in endocrine tissues.
StAR expression is highly enriched in organs responsible for steroid hormone synthesis, including the adrenal cortex, testicular Leydig cells, and ovarian theca and luteal cells. In these tissues, cholesterol transport into mitochondria is essential for the initiation of steroid hormone synthesis pathways that generate glucocorticoids, mineralocorticoids, and sex steroids. The presence of StAR protein therefore reflects the steroidogenic capacity of these endocrine cells and is closely linked to hormone production activity within adrenal and gonadal tissues.
Regulation of StAR expression is tightly controlled by endocrine signaling pathways. Hormones such as adrenocorticotropic hormone in the adrenal cortex and luteinizing hormone in gonadal tissues stimulate steroidogenesis by increasing StAR transcription and mitochondrial cholesterol transport activity. Through this mechanism, StAR functions as a key regulatory point that integrates hormonal signals with steroid hormone production. Alterations in StAR expression or activity can disrupt steroid hormone synthesis and are associated with endocrine disorders affecting adrenal or gonadal function.
StAR is also relevant in the study of endocrine tumors and steroidogenic lineage differentiation. Adrenocortical tumors and certain gonadal neoplasms may retain steroidogenic characteristics that involve continued expression of proteins required for steroid biosynthesis. Detection of Steroidogenic Acute Regulatory Protein can therefore provide insight into steroidogenic differentiation and endocrine tissue organization in experimental models examining adrenal and gonadal tumor biology.
Because StAR functions at the first regulated step of mitochondrial cholesterol transport during steroidogenesis, it has become a widely studied protein in endocrine physiology and hormone biosynthesis research. Antibodies targeting StAR enable investigation of steroidogenic cell populations, regulation of cholesterol transport into mitochondria, and signaling pathways controlling steroid hormone production in adrenal and gonadal tissues.
Optimal dilution of the StAR Antibody Recombinant Rabbit MAb STAR/3915R should be determined by the researcher.
A portion of amino acids 39-108 was used as the immunogen for the recombinant StAR antibody.
Aliquot the recombinant StAR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
StAR antibody, Steroidogenic acute regulatory protein antibody, STARD1 antibody, STAR protein antibody, Cholesterol transport protein StAR antibody
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