- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SOX9 Antibody / Pancreatic Ductal Marker Antibody [clone SOX9/3141R] (V8091)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8091-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8091-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8091SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | SOX9/3141R |
| Purity | Protein A affinity chromatography |
| UniProt | P48436 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This SOX9 Antibody / Pancreatic Ductal Marker Antibody is available for research use only. |
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SRY-box transcription factor 9 (SOX9) is a nuclear transcription factor that plays a central role in epithelial differentiation, organogenesis, and maintenance of progenitor cell populations, with particularly strong and consistent expression in pancreatic ductal epithelium. SOX9 Antibody is widely used to investigate epithelial lineage identity and is especially valuable as a pancreatic ductal marker in tissue-based studies. SOX9 Antibody / Pancreatic Ductal Marker Antibody enables precise identification of ductal epithelial cells within complex glandular tissues, supporting detailed histological and pathological evaluation.
In immunohistochemistry applications, SOX9 demonstrates robust nuclear staining in ductal epithelial cells of the pancreas, providing clear contrast with acinar and endocrine compartments that typically show minimal or absent signal. SOX9 antibody, also known as SRY-box transcription factor 9 antibody, is therefore commonly used to delineate ductal architecture in formalin-fixed, paraffin-embedded (FFPE) specimens. This distinct staining pattern is particularly useful in tissue microarray (TMA) analysis, where consistent nuclear labeling across multiple cores allows for comparative assessment of ductal differentiation across large panels of normal and diseased tissues.
SOX9 is a key regulator of pancreatic development and regeneration, maintaining ductal cell identity and supporting epithelial plasticity during injury and repair. In pathological contexts, SOX9 expression is frequently upregulated in pancreatic ductal adenocarcinoma (PDAC) and precursor lesions, where it contributes to tumor progression, dedifferentiation, and expansion of progenitor-like cell populations. SOX9 Antibody supports detection of these changes, enabling visualization of ductal lineage expansion and altered epithelial states in tumor tissue.
Beyond the pancreas, SOX9 is expressed in additional glandular and epithelial tissues including the gastrointestinal tract and biliary system, where it plays a role in maintaining epithelial integrity and regenerative capacity. However, its strong and reproducible nuclear staining in pancreatic ductal cells makes it particularly well suited as a lineage marker in this organ. In TMA-based studies, this allows for reliable comparison of SOX9 expression across diverse tissue types and disease states, including evaluation of tumor-associated epithelial remodeling.
In cancer research, SOX9 expression often correlates with aggressive tumor features, including enhanced proliferation, epithelial plasticity, and resistance to differentiation. Its involvement in transcriptional programs regulating epithelial identity underscores its importance in both normal development and malignancy. SOX9 Antibody provides a robust and reproducible tool for examining these processes in FFPE tissue sections and high-throughput tissue microarray formats.
Overall, SOX9 Antibody is well suited for immunohistochemical detection of pancreatic ductal epithelium and for studying epithelial differentiation, lineage specification, and tumor-associated changes. Its strong nuclear staining pattern and relevance to pancreatic pathology make it particularly valuable for TMA-based comparative tissue analysis and histopathological research.
This SOX9 antibody is part of a broader SOX9 antibody panel offered by NSJ Bioreagents.
Optimal dilution of the SOX9 Antibody / Pancreatic Ductal Marker Antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 393-508) was used as the immunogen for the recombinant SOX9 antibody.
Store the recombinant SOX9 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
SOX9 antibody, SRY-box transcription factor 9 antibody, SOX9 pancreatic marker antibody, SOX9 ductal marker antibody, SOX9 immunohistochemistry antibody
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