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Home >> Antibodies >> Recombinant Retinol Binding Protein 4 Antibody / RBP4

Recombinant Retinol Binding Protein 4 Antibody / RBP4 [clone RBP4/7045R] (V9568)

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  Catalog No Formulation Size Price (USD)  
Image V9568-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9568-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9568SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human liver tissue with recombinant Retinol Binding Protein 4 antibody (clone RBP4/7045R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human liver tissue with recombinant Retinol Binding Protein 4 antibody (clone RBP4/7045R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human kidney tissue with recombinant Retinol Binding Protein 4 antibody (clone RBP4/7045R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant Retinol Binding Protein 4 antibody (clone RBP4/7045R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name RBP4/7045R
Purity Protein A/G affinity
UniProt P02753
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant Retinol Binding Protein 4 antibody is available for research use only.
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Description

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

Application Notes

Optimal dilution of the recombinant Retinol Binding Protein 4 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 29-148 was used as the immunogen for the recombinant Retinol Binding Protein 4 antibody.

Storage

Aliquot the recombinant Retinol Binding Protein 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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