- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PTH Antibody N-Terminus / Rabbit Monoclonal [clone PTH/2295R] (V3644)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3644-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3644-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3644SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3644IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PTH/2295R |
| Purity | Protein A affinity chromatography |
| UniProt | P01270 |
| Localization | Cytoplasmic and secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PTH antibody is available for research use only. |
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Parathyroid hormone (PTH), encoded by the PTH gene, is a peptide hormone produced by endocrine chief cells of the parathyroid glands and serves as a central regulator of calcium and phosphate homeostasis. Through actions on bone, kidney, and vitamin D metabolism, PTH maintains systemic mineral balance and supports normal skeletal physiology. PTH Antibody N-Terminus recognizes the amino-terminal region of Parathyroid hormone and enables detection of the biologically active portion of the hormone in endocrine research and tissue analysis.
The N-terminal region of PTH contains the biologically active peptide segment responsible for receptor activation and downstream signaling through the parathyroid hormone receptor. Antibodies directed toward this portion of the protein are commonly referred to in the literature as PTH N-terminal antibody, PTH N-terminus antibody, or Parathyroid hormone N-terminal antibody, reflecting recognition of the amino-terminal domain of the hormone. Because this region includes the functionally important sequence responsible for receptor binding, antibodies recognizing the N-terminus are valuable tools for studying hormone biosynthesis, processing, and receptor signaling mechanisms.
PTH is synthesized in parathyroid chief cells as preproparathyroid hormone and subsequently processed intracellularly to generate the mature peptide hormone prior to secretion. In tissue sections, antibodies recognizing PTH typically demonstrate cytoplasmic localization within parathyroid endocrine cells where hormone synthesis and storage occur. Visualization of this staining pattern enables identification of hormone-producing cells within parathyroid gland tissue and supports research examining endocrine cell populations and parathyroid gland biology.
PTH antibodies are widely used in endocrine pathology and research involving parathyroid tissue and related tumors. Detection of PTH expression assists in confirming parathyroid origin in endocrine lesions and contributes to characterization of parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma. Because parathyroid tissue may be difficult to distinguish morphologically from surrounding thyroid structures in some specimens, immunodetection using a PTH antibody provides an important molecular marker for identifying hormone-producing parathyroid cells.
The specificity of clone PTH/2295R has been evaluated using a high-density human protein microarray containing thousands of full-length proteins, enabling large-scale assessment of antibody target recognition. Such protein microarray validation provides an orthogonal method to evaluate antibody specificity by confirming preferential binding to Parathyroid hormone relative to other proteins on the array. This approach supports the use of this recombinant rabbit monoclonal antibody for studies investigating Parathyroid hormone biology, endocrine signaling pathways, and epitope-specific detection of the PTH N-terminal region.
Optimal dilution of the PTH Antibody N-Terminus should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the recombinant PTH antibody.
Store the recombinant PTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Parathyroid hormone antibody, PTH antibody, Parathyroid hormone N-terminal antibody, PTH N-terminal antibody
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