- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
POSTN Antibody / Periostin Stromal Marker Antibody [clone rPOSTN/8522] (V4311)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4311-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4311-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4311SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rPOSTN/8522 |
| Purity | Protein A/G affinity |
| UniProt | Q15063 |
| Localization | Secreted, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT Western Blot : 2-4ug/ml |
| Limitations | This POSTN antibody is available for research use only. |
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Periostin (POSTN) is a secreted extracellular matrix glycoprotein that plays a critical role in stromal organization, tissue remodeling, and cell-matrix interactions. Periostin (POSTN), also known as osteoblast specific factor 2, is widely expressed in fibroblasts and stromal compartments where it contributes to extracellular matrix assembly and structural support. POSTN Antibody / Periostin Stromal Marker Antibody is particularly useful for identifying stromal activation and extracellular matrix remodeling in tissue sections and experimental models. POSTN is prominently expressed in connective tissues including lung, skin, and cardiovascular structures, and is strongly associated with fibroblast activity and matrix deposition.
POSTN antibody, also referred to as Periostin antibody or osteoblast specific factor 2 antibody, recognizes a matricellular protein that interacts with integrins and other extracellular matrix components to regulate cell adhesion, migration, and survival. Periostin contains fasciclin-like domains that mediate binding to integrins such as alpha v beta 3 and alpha v beta 5, activating downstream signaling pathways involved in cell motility and extracellular matrix organization. As a secreted protein, POSTN is deposited into the extracellular space, where it integrates into collagen-rich matrices and supports structural and signaling functions within tissues.
This POSTN Antibody / Periostin Stromal Marker Antibody is supported by western blot data demonstrating detection of periostin in human tissue lysates, with a band observed in the expected molecular weight range for glycosylated POSTN. The protein typically migrates within a broad range due to isoform diversity and post-translational modification, consistent with its extracellular matrix-associated function. This antibody is well suited for studies focused on stromal biology, where periostin expression reflects active matrix remodeling and fibroblast involvement.
Periostin is strongly induced during wound healing, fibrosis, and tumor progression, where it contributes to extracellular matrix deposition and stromal expansion. In fibrotic tissues, elevated POSTN levels are associated with increased matrix stiffness and altered tissue architecture. In cancer, periostin is frequently enriched in tumor-associated stroma and has been linked to enhanced tumor growth, invasion, and metastatic potential. Its expression is commonly observed in fibroblasts and cancer-associated stromal cells, making it a valuable marker for analyzing tumor microenvironment composition.
In addition to its structural role, POSTN participates in signaling pathways that regulate cell survival and mechanotransduction. Through interactions with integrins and activation of pathways such as PI3K/AKT and focal adhesion kinase, periostin influences cell proliferation, migration, and resistance to apoptosis. These functions are particularly relevant in tissues undergoing mechanical stress and remodeling, including cardiovascular and fibrotic environments. A POSTN antibody can be used in western blot, immunohistochemistry, or other research assays to evaluate periostin expression in stromal compartments, supporting studies in fibrosis, cancer biology, and extracellular matrix dynamics.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the recombinant POSTN antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 193-326) from the human protein was used as the immunogen for the recombinant POSTN antibody.
Aliquot the POSTN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PN antibody, POSTN antibody, Periostin antibodyPOSTN antibody, Periostin antibody, Osteoblast specific factor 2 antibody, OSF-2 antibody, Periostin stromal antibody
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