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It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.
Optimal dilution of the recombinant Podoplanin antibody should be determined by the researcher.
A portion of amino acids 1-100 from the human protein was used as the immunogen for the recombinant Podoplanin antibody.
Store the recombinant Podoplanin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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