- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX8 Antibody / Mullerian Epithelial Marker Antibody [clone rPAX8/1492] (V8168)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8168-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8168-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8168SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rPAX8/1492 |
| Purity | Protein G affinity chromatography |
| UniProt | Q06710 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This PAX8 antibody is available for research use only. |
|
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Paired box protein Pax-8 (PAX8) is a nuclear transcription factor encoded by the PAX8 gene that plays an important role in the development and maintenance of Mullerian-derived epithelial tissues. These tissues include fallopian tube, endometrium, and ovarian surface epithelium, where PAX8 regulates transcriptional programs essential for epithelial differentiation and tissue identity. PAX8 antibody is widely used as a marker of Mullerian lineage due to its consistent nuclear expression in these cell types.
PAX8 antibody, also known as Paired box protein Pax-8 antibody or Pax-8 transcription factor antibody, is strongly expressed in epithelial cells of the female reproductive tract. This PAX8 Antibody is uniquely positioned for studies focused on Mullerian epithelial biology, enabling identification of lineage-specific cells within both normal and neoplastic tissues. Nuclear localization reflects its role as a transcription factor controlling gene expression programs that define epithelial phenotype.
During development, PAX8 contributes to formation of Mullerian ducts and differentiation of reproductive tract epithelia. In adult tissues, it supports maintenance of epithelial structure, hormone responsiveness, and functional specialization. Its activity is essential for preserving the identity and integrity of these tissues over time.
Functionally, PAX8 regulates genes involved in epithelial organization and differentiation, contributing to cellular stability and tissue homeostasis. It interacts with other transcriptional regulators to coordinate gene expression networks that maintain reproductive tract physiology. Disruption of these pathways can contribute to disease, including tumorigenesis.
In cancer biology, PAX8 expression is commonly observed in ovarian epithelial tumors, including serous, endometrioid, and clear cell carcinomas, as well as in endometrial carcinomas. Nuclear staining is used to support classification of tumors of Mullerian origin and to distinguish them from non-gynecologic malignancies. Its presence provides strong evidence of lineage identity in histopathological analysis.
PAX8 Antibody therefore provides a targeted tool for studying Mullerian epithelial differentiation and tumor classification. Its lineage-restricted nuclear expression supports research into reproductive tissue development, epithelial biology, and gynecologic cancers, enabling accurate identification of Mullerian-derived cells within complex tissue environments.
Optimal dilution of the PAX8 Antibody / Mullerian Epithelial Marker Antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 60-261) was used as the immunogen for this PAX8 Antibody / Mullerian Epithelial Marker Antibody.
Store the recombinant PAX8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
PAX8 Mullerian marker antibody, Paired box protein Pax-8 gynecologic epithelial antibody, PAX8 ovarian epithelial marker antibody, Pax-8 fallopian tube marker antibody, PAX8 endometrial lineage antibody
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