- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PAX6 Antibody Rabbit Monoclonal PAX6/7078R [clone PAX6/7078R] (V8853)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8853-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V8853-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8853SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PAX6/7078R |
| Purity | Protein A/G affinity |
| UniProt | P26367 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This PAX6 antibody is available for research use only. |
|
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Paired box protein Pax-6 (PAX6) is a nuclear transcription factor encoded by the PAX6 gene and is widely recognized as a master regulator of eye and nervous system development. The protein belongs to the paired box family of transcription factors and functions as a key regulator of gene expression during embryogenesis. PAX6 Antibody Rabbit Monoclonal PAX6/7078R recognizes Pax-6 and supports research investigating transcriptional regulation in developmental biology and neural differentiation.
PAX6 plays a critical role in formation of the eye, brain, and olfactory system. During embryonic development, Pax-6 regulates transcriptional networks that guide morphogenesis of ocular tissues including the retina, lens, and cornea. In the developing central nervous system, PAX6 is expressed in neural progenitor cells and contributes to regional patterning and neuronal lineage specification. Because of its fundamental developmental roles, Pax-6 expression is frequently examined in studies of neurogenesis, stem cell differentiation, and organogenesis.
The PAX6 protein contains several functional domains that enable precise control of gene transcription. The N-terminal paired domain binds specific DNA sequences in target gene promoters and enhancers, while the homeodomain provides additional DNA-binding capability. A C-terminal proline-serine-threonine rich transactivation domain interacts with transcriptional co-regulators to control gene expression. Through these domains Pax-6 coordinates transcription of genes required for tissue specification and cellular differentiation.
Mutations or altered expression of PAX6 can lead to developmental abnormalities affecting the eye and nervous system. Genetic mutations in the PAX6 gene are associated with aniridia and other congenital ocular disorders characterized by defects in iris formation and visual system development. Because Pax-6 regulates numerous developmental pathways, the protein remains a central focus of research in developmental genetics and molecular biology.
PAX6 antibody reagents are commonly described in the literature using several related protein names including PAX6 antibody, Pax-6 antibody, paired box protein Pax-6 antibody, and aniridia type II protein antibody. These terms all refer to the transcription factor encoded by the PAX6 gene. PAX6 Antibody Rabbit Monoclonal PAX6/7078R recognizes Pax-6 protein and supports research focused on transcriptional regulation, neural development, and gene expression pathways associated with embryonic tissue patterning.
Optimal dilution of the PAX6 Antibody Rabbit Monoclonal PAX6/7078R should be determined by the researcher.
A portion of amino acids 1-300 was used as the immunogen for the recombinant PAX6 antibody.
Aliquot the PAX6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Pax-6 antibody, paired box protein Pax-6 antibody, aniridia type II protein antibody, Pax6 transcription factor antibody
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