- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Parathyroid Hormone IHC Antibody / PTH Antibody / N-Terminal Rabbit Monoclonal [clone PRTM1-1R] (V3765)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3765-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3765-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3765SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3765IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PRTM1-1R |
| Purity | Protein A affinity chromatography |
| UniProt | P01270 |
| Localization | Cytoplasmic and secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This Parathyroid Hormone antibody is available for research use only. |
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Parathyroid hormone (PTH), encoded by the PTH gene, is a peptide hormone produced by endocrine chief cells of the parathyroid glands and serves as a central regulator of calcium and phosphate homeostasis. Through effects on bone remodeling, renal calcium reabsorption, and vitamin D activation, PTH maintains systemic mineral balance. Parathyroid Hormone IHC Antibody / PTH Antibody enables immunohistochemistry detection of PTH in formalin-fixed paraffin-embedded tissue sections, allowing visualization of hormone-producing parathyroid cells in histological specimens commonly examined in endocrine pathology.
Parathyroid Hormone IHC Antibody clone PRTM1-1R is a recombinant rabbit monoclonal antibody developed for sensitive detection of PTH protein in tissue sections using immunohistochemistry. In FFPE samples, PTH immunohistochemistry typically produces strong cytoplasmic staining in parathyroid chief cells, reflecting intracellular synthesis and storage of the hormone prior to secretion. This staining pattern allows clear identification of parathyroid endocrine tissue within surgical specimens and supports studies examining hormone-producing cell populations in histological sections.
PTH immunohistochemistry is widely used in diagnostic pathology to confirm parathyroid origin in endocrine tumors of the neck region. Strong cytoplasmic staining observed with a PTH antibody can assist in distinguishing parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma from morphologically similar thyroid lesions or metastatic tumors. Because parathyroid glands may be small or ectopic in surgical samples, immunohistochemistry detection of PTH provides an important molecular marker for confirming parathyroid tissue identity.
The PTH protein is synthesized as preproparathyroid hormone and undergoes intracellular processing before secretion as the biologically active peptide hormone. Immunohistochemistry detection therefore highlights cytoplasmic localization within hormone-producing endocrine cells of the parathyroid gland. Visualization of this staining pattern using a Parathyroid Hormone antibody enables researchers and pathologists to evaluate endocrine cell distribution and hormone expression within tissue sections.
This recombinant rabbit monoclonal antibody clone PRTM1-1R recognizes Parathyroid hormone and is suitable for immunohistochemistry-based detection of PTH expression in FFPE tissue sections. A Parathyroid Hormone IHC Antibody supports research and diagnostic studies involving parathyroid gland biology, endocrine tumor pathology, and histological analysis of hormone-producing cells.
The stated application concentrations are suggested starting points. Titration of the Parathyroid Hormone IHC Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the recombinant Parathyroid Hormone antibody.
Store the recombinant Parathyroid Hormone antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
PTH antibody, Parathyroid hormone antibody, Parathyroid hormone immunohistochemistry antibody, PTH immunohistochemistry antibody
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