- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant p63 antibody detects tumor protein p63, encoded by the TP63 gene. p63 is a transcription factor belonging to the p53 family, where it regulates epithelial development, stem cell maintenance, and differentiation. Because of its critical role in epithelial biology and its altered expression in cancer, Recombinant p63 antibody is indispensable in oncology, developmental biology, and transcriptional research.
p63 exists in multiple isoforms generated by alternative promoters and splicing, including TAp63 isoforms that contain an N-terminal transactivation domain and ÎNp63 isoforms that lack it. These isoforms perform distinct biological functions, from promoting cell survival to regulating apoptosis and differentiation. Expression of ÎNp63, often referred to as p40, is particularly enriched in squamous epithelium and squamous cell carcinomas, making it a valuable diagnostic marker.
The Recombinant p63 antibody clone TP63/4379R provides reliable and reproducible detection. Recombinant production ensures batch-to-batch consistency, supporting applications that require precision. Clone TP63/4379R has been cited in peer-reviewed studies examining squamous cell carcinoma, epithelial stem cells, and developmental regulation. Its versatility supports immunohistochemistry, Western blotting, and other assays focused on transcription factor expression.
Research using clone TP63/4379R has clarified how p63 expression defines basal epithelial cells and helps distinguish squamous carcinomas from adenocarcinomas. In developmental biology, p63 detection has revealed how this transcription factor regulates limb and craniofacial morphogenesis. In oncology, altered expression of p63 isoforms has been linked to tumor initiation, progression, and response to therapy. This antibody has supported mechanistic studies exploring how p63 integrates developmental and oncogenic signaling pathways.
NSJ Bioreagents supplies this Recombinant p63 antibody to support oncology, pathology, and developmental biology. Alternate designations include TP63 antibody, tumor protein 63 antibody, ÎNp63 antibody, p40 antibody, epithelial stem cell marker antibody, and transcription factor p63 antibody.
Optimal dilution of the recombinant p63 antibody should be determined by the researcher.
A portion of amino acids 600-680 was used as the immunogen for the recombinant p63 antibody.
Aliquot the recombinant p63 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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