- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant p63 Antibody / TP63 / Rabbit Monoclonal [clone TP63/1423R] (V3815)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3815-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V3815-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
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V3815SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | TP63/1423R |
| Purity | Protein A affinity chromatography |
| UniProt | Q9H3D4 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This recombinant p63 antibody is available for research use only. |
|
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Recombinant p63 antibody detects tumor protein p63, a transcription factor encoded by the TP63 gene and a member of the p53 family. P63 regulates epithelial development, stem cell maintenance, and cellular differentiation. It is expressed in basal layers of stratified epithelia such as skin, prostate, and urothelium. Because of its involvement in both development and cancer, p63 is a critical subject of research in dermatology, oncology, and regenerative medicine.
P63 exists in multiple isoforms, broadly categorized into TAp63 and ÎNp63, which have distinct transcriptional activities. TAp63 isoforms promote differentiation and apoptosis, while ÎNp63 isoforms support proliferation and stemness. This functional diversity allows p63 to orchestrate epithelial development and tissue homeostasis. Dysregulated expression is linked to squamous cell carcinomas and developmental disorders affecting the skin and limbs.
The Recombinant p63 antibody clone TP63/1423R ensures specific and reproducible recognition. Recombinant technology guarantees consistent lot-to-lot performance, making it well suited for long-term projects. Clone TP63/1423R has been widely employed in cancer diagnostics, where p63 expression helps distinguish squamous cell carcinomas from adenocarcinomas. It has also been cited in peer-reviewed publications that investigate epithelial stem cells, tissue regeneration, and tumor biology, highlighting its reliability in diverse fields.
Research using clone TP63/1423R has clarified how p63 expression defines basal epithelial cells and informs tumor classification. In oncology, p63 staining is a key diagnostic tool for identifying squamous differentiation. In developmental biology, p63 detection contributes to understanding epithelial morphogenesis and regeneration following injury. This antibody continues to support research across fundamental and clinical applications.
NSJ Bioreagents provides this Recombinant p63 antibody to support studies in epithelial biology, cancer pathology, and regenerative medicine. The protein is also described as TP63 antibody, transformation-related protein 63 antibody, squamous cell carcinoma marker antibody, and epithelial stem cell transcription factor antibody.
Optimal dilution of the recombinant p63 antibody should be determined by the researcher.
Full-length human recombinant protein was used as the immunogen for the recombinant p63 antibody.
Store the recombinant p63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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