- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant p53 Antibody / Rabbit Monoclonal [clone CTA53-2R] (V3750)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3750-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
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V3750-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V3750SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 | |
|
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V3750IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CTA53-2R |
| Purity | Protein A affinity chromatography |
| UniProt | P04637 |
| Localization | Predominantly nuclear |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This recombinant p53 antibody is available for research use only. |
|
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Recombinant p53 antibody provides a dependable method for detecting tumor protein p53, a transcription factor encoded by the TP53 gene. Often referred to as the guardian of the genome, p53 preserves genomic stability by regulating DNA repair, cell cycle arrest, senescence, and apoptosis. Because mutations in TP53 occur in more than half of human cancers, p53 remains one of the most studied tumor suppressors in biology and medicine.
In normal physiology, p53 protein levels are tightly controlled by MDM2 mediated ubiquitination and degradation. Upon DNA damage, oncogenic stress, or hypoxia, p53 becomes stabilized and accumulates in the nucleus, where it activates or represses numerous target genes. This broad regulatory network prevents malignant transformation by halting proliferation or inducing cell death when genomic integrity is compromised.
The Recombinant p53 antibody clone CTA53-2R provides accurate and reproducible recognition. Recombinant technology ensures lot-to-lot consistency, enabling dependable comparisons across studies. Clone CTA53-2R has been employed in oncology to examine tumor suppressor function, in cell biology to study stress responses, and in developmental research to investigate checkpoint regulation. Multiple peer-reviewed publications have cited the use of this clone in cancer research, further validating its reliability in experimental contexts.
Research with clone CTA53-2R has clarified how loss of p53 activity contributes to uncontrolled proliferation, genomic instability, and therapy resistance. It also supports translational research into therapeutic approaches designed to restore p53 function in tumors. Beyond oncology, p53 detection informs studies of aging, stress adaptation, and stem cell regulation. This antibody continues to aid basic and applied investigations into one of the most important proteins in biomedical research.
NSJ Bioreagents supplies this Recombinant p53 antibody to support studies in cancer biology, transcriptional regulation, and stress signaling. The protein is also described as TP53 antibody, tumor suppressor p53 antibody, cellular tumor antigen p53 antibody, and guardian of the genome antibody.
Optimal dilution of the recombinant p53 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant human protein was used as the immunogen for this recombinant p53 antibody.
Store the recombinant p53 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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