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Home >> Antibodies >> Recombinant p21WAF1 Antibody / CDKN1A

Recombinant p21WAF1 Antibody / CDKN1A [clone rCIP1/6907] (V9525)

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  Catalog No Formulation Size Price (USD)  
Image V9525-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9525-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9525SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human colon carcinoma tissue with recombinant p21WAF1 antibody (clone rCIP1/6907) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human colon carcinoma tissue with recombinant p21WAF1 antibody (clone rCIP1/6907) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Negative control: IHC staining of FFPE human brain tissue using recombinant p21WAF1 antibody (clone rCIP1/6907) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant p21WAF1 antibody (clone rCIP1/6907) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rCIP1/6907
Purity Protein A/G affinity
UniProt P38936
Localization Nuclear
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant p21WAF1 antibody is available for research use only.
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Description

This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Application Notes

Optimal dilution of the recombinant p21WAF1 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 1-100 was used as the immunogen for the recombinant p21WAF1 antibody.

Storage

Aliquot the recombinant p21WAF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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