- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant Napsin A antibody detects Napsin A, an aspartic proteinase encoded by the NAPSA gene. Napsin A is primarily expressed in type II pneumocytes of the lung and in renal tubules, where it participates in protein catabolism and surfactant protein maturation. Because of its restricted expression and strong association with pulmonary adenocarcinoma, Recombinant Napsin A antibody is widely applied in oncology, pathology, and pulmonary biology.
Napsin A belongs to the aspartic protease family and functions in the processing of surfactant protein B, which is essential for proper lung function. Its tissue-specific distribution makes it a valuable biomarker for distinguishing lung adenocarcinoma from squamous carcinoma and other tumor types. Unlike markers that lack specificity, Napsin A expression provides reliable evidence of pulmonary origin in metastatic lesions.
The Recombinant Napsin A antibody clone NAPSA/4400R provides consistent and reproducible recognition of this protease. Recombinant technology ensures lot-to-lot uniformity, critical for longitudinal studies. Clone NAPSA/4400R has been cited in peer-reviewed publications examining lung adenocarcinoma pathology and diagnostic marker panels. Its applications include immunohistochemistry, immunoblotting, and cytological assays.
Research using clone NAPSA/4400R has shown that Napsin A expression complements thyroid transcription factor 1 (TTF-1) as part of diagnostic panels for lung adenocarcinoma. In renal pathology, detection of Napsin A has aided in identifying primary renal neoplasms and differentiating them from metastatic tumors. Beyond oncology, studies have investigated the role of Napsin A in protein turnover within alveolar cells, linking it to surfactant homeostasis and pulmonary physiology.
NSJ Bioreagents supplies this Recombinant Napsin A antibody to support oncology, pulmonary biology, and pathology. Alternate terms include NAPSA antibody, aspartic proteinase 4 antibody, lung adenocarcinoma marker antibody, surfactant processing enzyme antibody, and renal tubular marker antibody.
Optimal dilution of the recombinant Napsin A antibody should be determined by the researcher.
A portion of amino acids 50-150 from the human protein was used as the immunogen for the recombinant Napsin A antibody.
Store the recombinant Napsin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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