- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Mucin 5AC Antibody / Secreted Mucin Marker [clone MUC5AC/7066R] (V9680)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9680-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9680-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9680SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | MUC5AC/7066R |
| Purity | Protein A/G affinity |
| UniProt | P98088 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Mucin 5AC Antibody / Secreted Mucin Marker is available for research use only. |
|
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Mucin 5AC Antibody / Secreted Mucin Marker detects MUC5AC, a large secreted gel-forming mucin produced by specialized mucus-secreting epithelial cells. MUC5AC is an important structural component of mucus in the stomach and respiratory tract, where it contributes to hydrated extracellular barriers that protect epithelial surfaces. Through its extensive glycosylation and ability to form mucus gels, Mucin 5AC contributes to mucosal defense against microorganisms, environmental particles, chemical injury and dehydration.
MUC5AC contains large serine- and threonine-rich regions that undergo extensive O-linked glycosylation. These carbohydrate-rich domains give mature mucin molecules their characteristic physical properties and resistance to proteolysis. Following secretion, MUC5AC contributes to formation of viscoelastic mucus gels that trap particles and microorganisms while maintaining hydration of epithelial surfaces. This secreted mucin biology makes MUC5AC relevant to research involving epithelial barrier function, mucus production and mucosal homeostasis.
In the respiratory tract, MUC5AC is produced by goblet and other mucus-secreting epithelial cells. Its expression can increase in response to inflammatory cytokines, allergens, infection and environmental irritants. Excessive MUC5AC production can contribute to mucus accumulation and impaired airway clearance, making the protein important to studies of asthma, chronic bronchitis, chronic obstructive pulmonary disease and other conditions involving mucus hypersecretion.
Mucin 5AC is also highly expressed by surface and foveolar epithelial cells of the stomach, where it contributes to the mucus barrier protecting the gastric mucosa from acid and digestive enzymes. Changes in MUC5AC expression, localization and glycosylation are investigated in gastritis, Helicobacter pylori infection, gastric epithelial remodeling and cancer. Aberrant expression is additionally studied in other epithelial malignancies, particularly tumors showing mucinous or gastric-type differentiation.
Clone MUC5AC/7066R is a recombinant rabbit monoclonal antibody generated against full-length recombinant human protein. It has been evaluated by immunohistochemistry in FFPE human tissues. Recombinant production provides a defined antibody sequence and supports consistent performance across manufacturing lots. NSJ Bioreagents supplies antibodies for mucin, epithelial and mucosal biology research. A Mucin 5AC Antibody can be used to investigate secreted mucus, epithelial barrier function, mucosal defense and disease-associated changes in MUC5AC expression.
For broader research on MUC5AC expression in gastric and respiratory mucus, including the widely published 45M1 clone, see our MUC5AC Antibody 45M1 / Gastric and Respiratory Mucin Marker page.
Optimal dilution of the Mucin 5AC Antibody / Secreted Mucin Marker should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the recombinant Mucin 5AC antibody.
Aliquot the recombinant Mucin 5AC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Mucin 5AC antibody, Secreted Mucin Marker antibody, MUC5AC antibody, Mucin-5AC antibody, Gastric Mucin antibody
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