- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant MUC1 Antibody / Mucin 1 / EMA [clone r115D8] (V5491)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5491-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5491-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5491SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | r115D8 |
| Purity | Protein A/G affinity |
| UniProt | P15941 |
| Localization | Cytoplasm, Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant MUC1 antibody is available for research use only. |
|
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Recombinant MUC1 antibody (clone r115D8) targets Mucin 1, a transmembrane glycoprotein encoded by the human MUC1 gene and a member of the membrane-bound mucin family. Mucin 1, also widely referred to as MUC1 and epithelial membrane antigen in the literature, is primarily localized to the apical surface of epithelial cells where it contributes to mucosal barrier protection and intracellular signaling. Recombinant MUC1 antibody clone r115D8 is designed to detect Mucin 1 expression in epithelial tissues and carcinoma models where MUC1 is frequently overexpressed and aberrantly glycosylated.
MUC1 is synthesized as a large precursor that undergoes autocatalytic cleavage into two subunits that remain non-covalently associated at the cell surface. Its extracellular domain contains variable number tandem repeats that are extensively O-glycosylated, forming a protective mucin layer on epithelial surfaces. In normal tissues, Mucin 1 expression is restricted to the apical membrane of glandular and ductal epithelial cells. In malignant transformation, MUC1 commonly loses apical polarity and becomes diffusely expressed across the cell membrane, with altered glycosylation patterns that expose peptide epitopes. Recombinant MUC1 antibody clone r115D8 is therefore valuable for investigating tumor-associated antigen expression and epithelial cell transformation.
The cytoplasmic tail of Mucin 1 participates in signaling pathways through interactions with beta-catenin and additional regulatory proteins, influencing proliferation, survival, and metastatic behavior. Elevated MUC1 expression has been documented in breast, ovarian, pancreatic, lung, gastric, and colorectal carcinomas, where it is frequently associated with aggressive disease. Because of its biological and clinical relevance, recombinant MUC1 antibody clone r115D8 supports studies of tumor progression and epithelial signaling mechanisms.
Structurally, Mucin 1 contains an extracellular mucin domain with tandem repeats, a transmembrane region, and a short cytoplasmic tail involved in signal transduction. A recombinant MUC1 antibody such as clone r115D8 is suitable for detecting Mucin 1 expression in epithelial tissues and cancer research applications.
Optimal dilution of the recombinant MUC1 antibody should be determined by the researcher.
Recombinant full-length human Mucin 1 protein was used as the immunogen for the recombinant MUC1 antibody.
Aliquot the recombinant MUC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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