- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant MSLN Antibody / Mesothelin [clone MSLN/8331R] (V5643)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5643-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5643-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5643SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MSLN/8331R |
| Purity | Protein A affinity |
| UniProt | Q13421 |
| Localization | Cell surface, Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 1-2ug/ml |
| Limitations | This recombinant MSLN antibody is available for research use only. |
|
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Recombinant MSLN Antibody recognizes Mesothelin, a glycosylphosphatidylinositol-anchored cell surface protein encoded by the MSLN gene. Mesothelin is normally expressed at low levels in mesothelial cells lining the pleura, peritoneum, and pericardium, where it localizes to the cell membrane. Recombinant MSLN Antibody clone MSLN/8331R is a rabbit monoclonal antibody developed for research applications investigating mesothelial biology and tumor-associated mesothelin expression.
Mesothelin is synthesized as a precursor protein that is proteolytically cleaved to generate a membrane-bound mature mesothelin fragment and a soluble fragment known as megakaryocyte potentiating factor. The membrane-associated form is frequently overexpressed in several epithelial malignancies, including malignant mesothelioma, ovarian carcinoma, pancreatic ductal adenocarcinoma, and subsets of lung and gastric carcinomas. In tumor cells, mesothelin expression is typically observed along the cell membrane, often with additional cytoplasmic staining depending on tissue processing and expression levels.
Because of its restricted distribution in normal tissues and elevated expression in certain cancers, mesothelin has been widely studied as a tumor-associated antigen in experimental oncology. Research efforts have focused on its role in cell adhesion, tumor progression, and interaction with other surface molecules. Mesothelin has also been explored as a target in therapeutic development and tumor biomarker research, increasing interest in reliable antibodies for detecting MSLN expression in tissue-based studies.
Recombinant MSLN Antibody clone MSLN/8331R provides a tool for evaluating mesothelin expression in human tissue samples and experimental models. This rabbit monoclonal antibody is suitable for research applications involving mesothelial tissues and mesothelin-expressing tumors.
Optimal dilution of the recombinant MSLN antibody should be determined by the researcher.
A portion of amino acids 250-450 from human Mesothelin protein was used as the immunogen for the recombinant MSLN antibody.
Aliquot the recombinant MSLN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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