- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MGB1 Antibody / Mammaglobin A Antibody / SCGB2A2 [clone MGB/4811R] (V9243)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9243-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9243-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9243SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | MGB/4811R |
| Purity | Protein A/G affinity |
| UniProt | Q13296 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This MGB1 antibody is available for research use only. |
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Mammaglobin A (SCGB2A2) is a secreted epithelial glycoprotein encoded by the SCGB2A2 gene and belongs to the secretoglobin family of small secreted proteins associated with mammary epithelial differentiation. MGB1 Antibody recognizes Mammaglobin A and targets a protein commonly referred to in the literature as Mammaglobin, Mammaglobin A, or SCGB2A2, a breast-associated secreted protein expressed primarily by mammary epithelial cells.
MGB1 antibody, also referred to as Mammaglobin A antibody or SCGB2A2 antibody in the literature, detects a protein that is highly associated with mammary gland epithelial cells. Mammaglobin A is produced by luminal epithelial cells within mammary glandular structures and is secreted into glandular lumens as part of epithelial secretory activity. This relatively restricted tissue expression pattern makes Mammaglobin an important molecular marker for studies of mammary epithelial biology and breast tumor origin.
Structurally, Mammaglobin A contains conserved cysteine residues typical of secretoglobin family proteins that contribute to protein folding and stability within the secretory pathway. As a secreted epithelial protein, Mammaglobin is commonly detected within the cytoplasm of mammary epithelial cells and may also be present within glandular luminal secretions depending on the tissue architecture and experimental preparation. These characteristics make Mammaglobin a useful molecular indicator of epithelial differentiation in mammary gland tissue.
Expression of Mammaglobin A is frequently observed in breast epithelial cells and breast carcinoma specimens, where it reflects the differentiated state of mammary epithelial tumor cells. In breast tumors, Mammaglobin expression is often detected within epithelial tumor cell populations forming glandular structures, while surrounding stromal cells typically show little to no expression. These expression patterns have led to Mammaglobin being widely studied in research focused on breast cancer biology and epithelial tumor characterization.
MGB1 Antibody (clone MGB/4811R) is a recombinant rabbit monoclonal antibody developed to detect Mammaglobin A / SCGB2A2 in protein expression studies. Antibodies against Mammaglobin are commonly used to investigate mammary epithelial cell differentiation, tumor cell identity, and protein localization in breast tissue and breast cancer research models.
Optimal dilution of the MGB1 antibody should be determined by the researcher.
Recombinant full-length human Mammaglobin/SCGB2A2 protein was used as the immunogen for the recombinant MGB1 antibody.
Aliquot the MGB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Mammaglobin antibody, Mammaglobin A antibody, SCGB2A2 antibody, Secretoglobin family 2A member 2 antibody, Mammary gland secretoglobin antibody
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