- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MCM7 Antibody Rabbit Monoclonal MCM7/2832R / Minichromosome Maintenance Protein 7 Antibody [clone MCM7/2832R] (V7508)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7508-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7508-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7508SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7508IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MCM7/2832R |
| Purity | Protein A affinity chromatography |
| UniProt | P33993 |
| Localization | Nuclear |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MCM7 antibody is available for research use only. |
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Minichromosome maintenance protein 7 (MCM7) is a nuclear DNA replication factor encoded by the MCM7 gene and functions as a key component of the minichromosome maintenance helicase complex responsible for eukaryotic DNA replication. MCM7 Antibody Rabbit Monoclonal MCM7/2832R recognizes this replication licensing protein and supports research focused on DNA synthesis, cell cycle progression, and proliferative signaling in normal and malignant cells.
MCM7 belongs to the conserved MCM protein family that forms the heterohexameric MCM2-7 helicase complex. This complex assembles at replication origins during the G1 phase of the cell cycle as part of the pre-replication complex, licensing chromatin for DNA synthesis. Once cells enter S phase, activation of the helicase enables separation of double-stranded DNA at replication forks, allowing DNA polymerases and associated replication machinery to duplicate the genome accurately during cell division.
MCM7 antibody, also referred to as CDC47 antibody and P1-MCM3 antibody in the literature, detects a nuclear protein strongly associated with proliferating cells. MCM7 localizes primarily to chromatin within the nucleus where it participates in replication origin licensing and helicase activation. Because expression of MCM7 correlates closely with cell cycle activity, the protein is frequently used as a marker of cellular proliferation in studies of tissue growth, regeneration, and tumor biology.
At the structural level, MCM7 contains conserved ATP-binding and ATP-hydrolysis domains characteristic of the AAA+ ATPase family. These domains supply the energy required for helicase activity, enabling conformational changes that drive DNA strand separation and replication fork progression. Tight regulation of this process ensures that chromosomal DNA is replicated only once per cell cycle, maintaining genomic stability and preventing aberrant DNA duplication.
Elevated expression of MCM7 has been reported in numerous cancers including colorectal carcinoma, breast cancer, lung cancer, and other rapidly proliferating malignancies. Increased levels of MCM proteins reflect heightened DNA replication activity in tumor cells and have made the complex widely studied in cancer biology and cell cycle research. A rabbit monoclonal antibody such as MCM7 Antibody Rabbit Monoclonal MCM7/2832R provides a useful tool for detecting Minichromosome maintenance protein 7 expression and investigating molecular mechanisms that regulate DNA replication and cellular proliferation.
Titering of the MCM7 Antibody Rabbit Monoclonal MCM7/2832R may be required for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A human recombinant partial protein corresponding to amino acids 195-319 was used as the immunogen for the recombinant MCM7 antibody.
Store the MCM7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CDC47 antibody, P1-MCM3 antibody, DNA replication licensing factor MCM7 antibody, Minichromosome maintenance protein 7 antibody, MCM7 replication factor antibody
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