- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
MBP Antibody / Oligodendrocyte Marker Antibody [clone rMBP/4288] (V8437)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8437-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8437-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8437SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rMBP/4288 |
| Purity | Protein G affinity chromatography |
| UniProt | P02686 |
| Localization | Cell surface, cytoplasm |
| Applications | Western Blot : 2-4ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This MBP Antibody / Oligodendrocyte Marker Antibody is available for research use only. |
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MBP Antibody / Oligodendrocyte Marker Antibody detects myelin basic protein (MBP), a major structural protein of the myelin sheath produced by oligodendrocytes in the central nervous system (CNS). Encoded by the MBP gene, myelin basic protein contributes to the formation and maintenance of compact myelin surrounding neuronal axons. MBP is abundant in CNS myelin and is widely studied in neuroscience as a marker of oligodendrocytes, myelination and myelin integrity.
MBP is a highly basic protein that associates with the cytoplasmic surface of myelin membranes. Its interactions with negatively charged membrane lipids help bring adjacent membrane layers together, contributing to the tightly compacted structure of mature myelin. Alternative splicing of the MBP gene generates multiple isoforms with differences in molecular weight and developmental expression. These isoforms are associated with different stages of oligodendrocyte development and myelin maturation.
As an oligodendrocyte marker, MBP is commonly investigated in studies of glial cell differentiation, CNS development, myelin formation and axon-glia interactions. Changes in MBP expression or integrity are also associated with myelin damage and are studied in experimental models of demyelination and remyelination. MBP is particularly relevant to multiple sclerosis and experimental autoimmune encephalomyelitis, where myelin proteins can become targets of immune responses.
Clone rMBP/4288 is a recombinant mouse monoclonal antibody generated against a region within amino acids 150-250 of human MBP. The antibody has been validated by immunohistochemistry using FFPE human cerebellum and by Western blot using human brain lysate, where MBP isoforms may be detected from approximately 20-37 kDa. These data support detection of MBP in human neural tissue and lysates.
NSJ Bioreagents supplies antibodies for research into neural proteins, glial cells and nervous system biology. An MBP Antibody can be used to investigate oligodendrocyte differentiation, myelin formation and MBP expression in studies of CNS development, myelin maintenance and neurological disease.
For broader research on myelin structure and MBP expression, see our Myelin Basic Protein Antibody / CNS Myelin Marker page.
Optimal dilution of the MBP Antibody / Oligodendrocyte Marker Antibody should be determined by the researcher.
A portion of amino acids 150-250 from the human protein was used as the immunogen for the recombinant MBP antibody.
Store the MBP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
MBP antibody, Myelin Basic Protein antibody, Oligodendrocyte Marker antibody, Myelin A1 Protein antibody
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![Myelin Basic Protein Antibody in Rat Brain IHC. Immunohistochemistry staining of FFPE rat brain tissue with Myelin Basic Protein Antibody / MBP [clone IIE-13]. HIER was performed in EDTA buffer, pH 8.0, followed by blocking with 10% goat serum. The antibody was used at 1:50 overnight at 4oC, followed by a peroxidase-conjugated goat anti-rabbit IgG secondary antibody and DAB detection. This Myelin Basic Protein Antibody demonstrates MBP localization in rat brain tissue.](https://www.nsjbio.com/plp/thumb_image/img-RQ5003-1.jpg?v=1789014827 "Myelin Basic Protein Antibody in Rat Brain IHC. Immunohistochemistry staining of FFPE rat brain tissue with Myelin Basic Protein Antibody / MBP [clone IIE-13]. HIER was performed in EDTA buffer, pH 8.0, followed by blocking with 10% goat serum. The antibody was used at 1:50 overnight at 4oC, followed by a peroxidase-conjugated goat anti-rabbit IgG secondary antibody and DAB detection. This Myelin Basic Protein Antibody demonstrates MBP localization in rat brain tissue.")
