- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ksp-Cadherin Antibody / Cadherin 16 [clone rCDH16/7343] (V5385)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5385-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5385-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5385SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rCDH16/7343 |
| Purity | Protein A/G affinity |
| UniProt | O75309 |
| Localization | Cell Surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Ksp-Cadherin antibody is available for research use only. |
|
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Cadherin-16 (CDH16), commonly known as Ksp-Cadherin, is a kidney-specific member of the cadherin superfamily that mediates calcium-dependent cell-cell adhesion in renal epithelial cells. Ksp-Cadherin is predominantly localized to the basolateral membrane of tubular epithelial cells in the kidney, where it contributes to the maintenance of epithelial integrity and tissue organization. The Ksp-Cadherin Antibody is designed to detect this tissue-restricted adhesion protein, making it a useful marker for renal epithelial identity and kidney-specific expression patterns.
Ksp-Cadherin antibody, also referred to as Cadherin-16 antibody or CDH16 antibody in the literature, recognizes a transmembrane glycoprotein that is selectively expressed in the distal nephron, including collecting ducts and segments of the distal tubule. Unlike many classical cadherins that are broadly expressed across tissues, CDH16 exhibits highly restricted expression, which supports its use as a kidney-specific epithelial marker. This restricted distribution is particularly valuable in studies focused on renal development, tissue differentiation, and epithelial cell lineage identification.
Structurally, Ksp-Cadherin contains multiple extracellular cadherin repeat domains responsible for calcium-dependent adhesion, a single transmembrane region, and a cytoplasmic tail that participates in intracellular signaling and cytoskeletal organization. Compared to other cadherins such as E-Cadherin or N-Cadherin, CDH16 has distinct sequence features that contribute to its tissue specificity and functional specialization within renal epithelium. The protein is also glycosylated, which can influence its apparent molecular weight on SDS-PAGE and may result in slight variability in migration depending on tissue context and processing state.
Functionally, CDH16 plays a role in maintaining epithelial polarity and structural cohesion within kidney tubules. Its expression supports tight intercellular contacts that are essential for proper tubular function, including fluid transport and barrier formation. Because of its selective expression, Ksp-Cadherin is frequently used as a marker to distinguish renal epithelial cells from other cell types in both normal tissue and disease models.
Altered expression of CDH16 has been associated with renal pathologies, including kidney injury and carcinoma, where disruption of epithelial architecture is a key feature. In renal cell carcinoma, changes in cadherin expression patterns can reflect dedifferentiation and tumor progression, making CDH16 a relevant marker for studying epithelial integrity and tumor biology within the kidney. Its specificity for renal tissue also supports its use in identifying metastatic lesions of kidney origin.
Clone rCDH16/7343 is a recombinant mouse monoclonal antibody designed to detect Ksp-Cadherin with specificity in kidney tissue. Its recognition of CDH16 supports applications in studies of renal epithelial biology, tissue organization, and kidney-associated disease, providing a reliable tool for investigating kidney-specific adhesion mechanisms and epithelial differentiation.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the Ksp-Cadherin antibody should be determined by the researcher.
Recombinant human full-length CDH16 protein was used as the immunogen for the recombinant Ksp-Cadherin antibody.
Aliquot the Ksp-Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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![Western blot testing of HEK293 lysate overexpressing human CDH11 with MYC tag with CDH11 antibody [1ug/ml] in Lane A and probed with anti-MYC tag [1/1000] in lane C. Mock-transfected HEK293 probed with CDH11 antibody [1ug/ml] in Lane B. Predicted molecular weight: ~88kDa but can be observed at 120-130kDa.](https://www.nsjbio.com/plp/thumb_image/img-R33226-100UG-1.jpg?v=1784834603 "Western blot testing of HEK293 lysate overexpressing human CDH11 with MYC tag with CDH11 antibody [1ug/ml] in Lane A and probed with anti-MYC tag [1/1000] in lane C. Mock-transfected HEK293 probed with CDH11 antibody [1ug/ml] in Lane B. Predicted molecular weight: ~88kDa but can be observed at 120-130kDa.")
![Western blot testing of HEK293 lysate overexpressing CDH11-MYC with CDH11 antibody [1ug/ml] in Lane A and with anti-MYC [1/1000] in lane C. Mock-transfected probed with anti-CDH11 [1ug/ml] in Lane B. Predicted molecular weight: ~88kDa but can be observed at 120-130kDa.](https://www.nsjbio.com/plp/thumb_image/img-R33977-100UG-1.jpg?v=1784834603 "Western blot testing of HEK293 lysate overexpressing CDH11-MYC with CDH11 antibody [1ug/ml] in Lane A and with anti-MYC [1/1000] in lane C. Mock-transfected probed with anti-CDH11 [1ug/ml] in Lane B. Predicted molecular weight: ~88kDa but can be observed at 120-130kDa.")
