- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT19 Antibody / Keratin 19 [clone KRT19/1959R] (V3618)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3618-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3618-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3618SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3618IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT19/1959R |
| Purity | Protein A affinity chromatography |
| UniProt | P08727 |
| Localization | Cytoplasmic, cell membrane, secreted |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This recombinant KRT19 antibody is available for research use only. |
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KRT19 Antibody recognizes Keratin 19, also known as Cytokeratin 19 (KRT19), a type I intermediate filament protein that is widely expressed in simple epithelial cells and in progenitor-associated epithelial compartments of stratified tissues. Keratin 19 is the smallest member of the type I keratin family and lacks the C-terminal tail domain present in most keratins, a structural feature that contributes to its distinctive filament organization and cellular distribution. KRT19 Antibody is commonly used in research and pathology contexts and is frequently referred to in the literature as Cytokeratin 19 antibody or CK19 antibody.
Cytokeratin 19 expression is characteristic of epithelial cells lining glandular and ductal structures, including bile ducts, pancreatic ducts, renal tubules, bronchial epithelium, gastrointestinal mucosa, mammary epithelium, and prostatic glands. In stratified epithelia, KRT19 expression is often enriched in basal or progenitor-associated epithelial cells rather than terminally differentiated suprabasal layers. This expression pattern distinguishes Cytokeratin 19 from differentiation-associated keratins such as Cytokeratin 10 or Cytokeratin 13 and makes KRT19 Antibody useful for identifying epithelial cells with ductal, glandular, or progenitor-like phenotypes.
Alterations in Keratin 19 expression have been reported in a variety of pathological contexts. Changes in CK19 expression patterns are frequently observed in epithelial-derived malignancies, including carcinomas of the breast, lung, pancreas, thyroid, liver, and gastrointestinal tract. As a result, Cytokeratin 19 antibody staining patterns are commonly evaluated in research studies focused on epithelial differentiation, ductal lineage identification, and carcinoma biology, particularly in tumors exhibiting glandular or ductal differentiation.
At the cellular level, Keratin 19 contributes to the organization of the intermediate filament cytoskeleton and supports epithelial cell integrity and structural adaptability. Its broad expression in simple and ductal epithelia makes KRT19 Antibody a valuable tool for studies of epithelial lineage tracing, tissue architecture, and epithelial biology. The KRT19 Antibody (clone KRT19/1959R) is designed to detect Keratin 19 expression in research applications where assessment of epithelial and ductal cell populations is required.
Optimal dilution of the recombinant KRT19 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Human mammary epithelial organoids were used as the immunogen for the recombinant KRT19 antibody.
Store the recombinant KRT19 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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