- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT18 Antibody / Cytokeratin 18 [clone rKRT18/7299] (V4280)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4280-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4280-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4280SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rKRT18/7299 |
| Purity | Protein A/G affinity |
| UniProt | P05783 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant KRT18 antibody is available for research use only. |
|
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KRT18 Antibody recognizes Cytokeratin 18, also known as Keratin 18 (KRT18), a type I intermediate filament protein that is broadly expressed in simple epithelial cells and epithelial-derived tissues. Cytokeratin 18 is a cytoplasmic structural protein that typically forms obligate heterodimers with type II keratins, most prominently Keratin 8, to assemble the intermediate filament network that maintains epithelial cell architecture, intracellular organization, and mechanical stability. KRT18 Antibody is commonly used in research and pathology contexts and is frequently referred to in the literature as Cytokeratin 18 antibody or CK18 antibody.
Cytokeratin 18 expression is characteristic of simple and glandular epithelia lining internal organs, including liver, pancreas, gastrointestinal tract, kidney, lung, and prostate. In these tissues, KRT18 is predominantly localized to luminal and secretory epithelial cells rather than basal cell compartments. This expression pattern distinguishes Cytokeratin 18 from basal keratins such as Cytokeratin 14 or Cytokeratin 15 and makes KRT18 Antibody useful for identifying epithelial cells of simple epithelial origin and for differentiating epithelial structures from surrounding stromal or mesenchymal tissue components.
Alterations in Cytokeratin 18 expression and organization have been documented in a range of pathological contexts. Changes in CK18 distribution, expression intensity, or filament organization have been observed in epithelial injury, cellular stress responses, and epithelial-derived malignancies. As a result, Cytokeratin 18 antibody staining patterns are frequently evaluated in research studies focused on epithelial differentiation, tissue remodeling, and carcinoma biology, particularly in tumors arising from glandular or ductal epithelia.
At the cellular level, Cytokeratin 18 contributes to the organization of the intermediate filament cytoskeleton and supports epithelial cell shape and resilience to mechanical and metabolic stress. Its broad expression across simple epithelial tissues makes KRT18 Antibody a valuable tool for studies of epithelial lineage identification, tissue architecture, and epithelial biology. The KRT18 Antibody (clone rKRT18/7299) is designed to detect Cytokeratin 18 expression in research applications where assessment of epithelial cell populations is required.
Optimal dilution of the recombinant KRT18 antibody should be determined by the researcher.
Recombinant full-length human protein was used as the immunogen for the recombinant KRT18 antibody.
Aliquot the recombinant KRT18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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