- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT13 Antibody / Cytokeratin 13 [clone rKRT13/9623] (V5478)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5478-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5478-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5478SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rKRT13/9623 |
| Purity | Protein A/G affinity |
| UniProt | P13646 |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant KRT13 antibody is available for research use only. |
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KRT13 antibody detects Keratin 13, a type I intermediate filament protein that is a key structural component of stratified squamous epithelia. Keratin 13 is also referred to as Cytokeratin 13 and is encoded by the KRT13 gene, which is predominantly expressed in non-keratinizing squamous epithelial tissues such as oral mucosa, esophagus, cervix, and upper aerodigestive tract epithelium. Within epithelial cells, Keratin 13 localizes to the cytoplasm where it forms obligate heterodimers with type II keratins, contributing to cytoskeletal integrity and mechanical resilience.
Keratin 13 is a member of the type I keratin family and is typically associated with differentiated suprabasal epithelial layers rather than basal progenitor compartments. Its expression pattern distinguishes non-keratinizing squamous epithelium from keratinizing epidermis, where keratins such as Keratin 1 and Keratin 10 predominate. For this reason, Cytokeratin 13 antibody reagents are widely used in epithelial classification studies and diagnostic research focused on mucosal differentiation states.
Loss or aberrant regulation of Keratin 13 expression has been documented in epithelial dysplasia and squamous cell carcinoma, particularly in the oral cavity and esophagus, where downregulation is associated with malignant transformation and altered differentiation programs. Conversely, retained KRT13 expression may support identification of benign or well-differentiated squamous epithelial lesions. These features make Keratin 13 antibody tools valuable for studying epithelial lineage fidelity, stratification, and disease-associated remodeling.
At the molecular level, Keratin 13 contributes to epithelial barrier stability and participates indirectly in signaling pathways that regulate differentiation and cellular stress responses. Its tissue-restricted expression profile, combined with consistent cytoplasmic localization, supports the use of KRT13 antibody reagents in research applications aimed at epithelial biology, mucosal pathology, and squamous tissue characterization. This Cytokeratin 13 antibody is designed to target Keratin 13 expression in relevant experimental contexts.
Optimal dilution of the recombinant KRT13 antibody should be determined by the researcher.
Esophageal keratins of rabbit origin were used as the immunogen for the recombinant KRT13 antibody.
Aliquot the recombinant KRT13 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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