- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
KRT10 Antibody / Cytokeratin 10 / CK10 [clone rKRT10/6923] (V4482)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4482-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4482-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4482SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rKRT10/6923 |
| Purity | Protein A/G affinity |
| UniProt | P13645 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant KRT10 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
KRT10 antibody recognizes Cytokeratin 10, a type I intermediate filament protein encoded by the KRT10 gene and a defining marker of suprabasal keratinocyte differentiation in stratified squamous epithelia. Keratin 10 is expressed as keratinocytes exit the basal proliferative layer and initiate terminal differentiation, where it pairs predominantly with Keratin 1 to form robust intermediate filament networks. These filaments provide mechanical resilience and structural stability to the epidermis, supporting barrier formation and resistance to physical stress. As such, KRT10 antibody reagents are widely used to study epidermal maturation, epithelial lineage specification, and keratinocyte differentiation programs.
In normal tissues, Keratin 10 expression is largely confined to the suprabasal layers of the epidermis and other stratified squamous epithelia, showing a characteristic cytoplasmic filamentous staining pattern. This restricted distribution makes KRT10 antibody a valuable complement to basal cell markers such as Keratin 5 and Keratin 14, allowing clear discrimination between proliferative basal keratinocytes and differentiated suprabasal cells. The tightly regulated spatial expression of Keratin 10 reflects its role in coordinating cytoskeletal reorganization during epidermal stratification and terminal differentiation.
Keratin 10 also has significant relevance in dermatopathology and epithelial tumor biology. Altered Cytokeratin 10 expression is observed in a range of hyperproliferative and inflammatory skin disorders, where reduced or aberrant staining reflects disrupted differentiation. In squamous cell carcinoma and related neoplasms, KRT10 antibody staining can assist in assessing tumor differentiation status, with well-differentiated lesions more likely to retain Keratin 10 expression compared with poorly differentiated tumors. Inherited disorders of keratinization, including epidermolytic hyperkeratosis, further highlight the functional importance of Keratin 10 in maintaining keratinocyte integrity.
At the molecular level, Keratin 10 belongs to the acidic type I keratin family and contains the conserved alpha-helical rod domain required for heterodimer formation and filament assembly. Its expression is regulated by calcium-dependent signaling and transcriptional pathways governing epidermal differentiation. A KRT10 antibody therefore provides a reliable tool for investigating epidermal biology, differentiation status, and disease-associated alterations in stratified squamous epithelia.
Optimal dilution of the recombinant KRT10 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 384-584) from the human protein was used as the immunogen for the recombinant KRT10 antibody.
Aliquot the recombinant KRT10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(10)
