- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Ki67 Antibody Mouse Monoclonal rMKI67/6615 / MKI67 Antibody [clone rMKI67/6615] (V9283)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9283-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9283-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9283SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rMKI67/6615 |
| Purity | Protein A/G affinity |
| UniProt | P46013 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant Ki67 antibody is available for research use only. |
|
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Ki-67 antigen (MKI67) is a nuclear proliferation-associated protein encoded by the MKI67 gene and widely used as a marker of actively cycling cells. Recombinant Ki67 Antibody Mouse Monoclonal rMKI67/6615 recognizes this well-established proliferation marker and supports detection of Ki-67 protein expression in studies focused on cell cycle progression, tumor growth, and proliferative signaling pathways. Because Ki-67 expression closely correlates with the cell cycle, detection of this protein is commonly used to evaluate cellular proliferation in cultured cells and tissue samples.
Ki67 antibody, also referred to as Ki-67 antibody or MKI67 antibody in the literature, detects a nuclear protein expressed during the G1, S, G2, and mitotic phases of the cell cycle but largely absent in quiescent cells in the G0 phase. This restricted expression pattern makes Ki-67 one of the most widely used markers of proliferating cells. Detection of Ki-67 allows investigators to distinguish actively cycling cells from resting cell populations within the same tissue or culture system.
Ki-67 participates in chromatin organization during cell division and exhibits dynamic localization throughout the cell cycle. During interphase the protein is localized within the nucleus and often associated with nucleolar regions. As cells enter mitosis, Ki-67 redistributes to the perichromosomal layer that surrounds condensed chromosomes, contributing to the maintenance of chromosome organization during mitotic progression.
Elevated Ki-67 expression is frequently observed in rapidly proliferating cell populations, including many cancer cell types. Because of this strong association with cellular proliferation, Ki-67 protein levels are commonly evaluated in studies of tumor biology, tissue regeneration, and cell cycle regulation. Detection of Ki-67 can provide insight into growth dynamics and the effects of treatments that influence cell cycle progression.
Recombinant Ki67 Antibody Mouse Monoclonal rMKI67/6615 supports detection of the Ki-67 / MKI67 proliferation marker in research applications focused on proliferative activity and cell cycle biology. This recombinant mouse monoclonal antibody enables investigators to analyze Ki-67 expression patterns and evaluate proliferating cell populations in experimental systems.
Optimal dilution of the Recombinant Ki67 Antibody Mouse Monoclonal rMKI67/6615 should be determined by the researcher.
A portion of amino acids 2293-2478 was used as the immunogen for the recombinant Ki67 antibody.
Aliquot the recombinant Ki67 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Ki67 antibody, Ki-67 antibody, MKI67 antibody, Antigen KI-67 antibody, Ki-67 proliferation marker antibody
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