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Home >> Antibodies >> Recombinant ITGB3 Antibody / Integrin beta 3 / CD61

Recombinant ITGB3 Antibody / Integrin beta 3 / CD61 [clone rITGB3/2145] (V7895)

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  Catalog No Formulation Size Price (USD)  
Image V7895-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V7895-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V7895SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC testing of FFPE human spleen with recombinant ITGB3 antibody (clone rITGB3/2145). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.
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IHC testing of FFPE human spleen with recombinant ITGB3 antibody. Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH9, for 10-20 min followed by cooling at RT for 20 min.
SDS-PAGE analysis of purified, BSA-free recombinant ITGB3 antibody as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rITGB3/2145
Purity Protein G affinity chromatography
UniProt P05106
Localization Cell surface, cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant ITGB3 antibody is available for research use only.
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Description

Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Application Notes

Optimal dilution of the recombinant ITGB3 antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein (amino acids 385-490) was used as the immunogen for this ITGB3 antibody.

Storage

Store the recombinant ITGB3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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