- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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INSM1 Antibody INSM1/6286R recognizes insulinoma-associated protein 1 (INSM1), a zinc finger transcription factor involved in the development and differentiation of endocrine and neuroendocrine cells. INSM1 was originally identified through its expression in insulinoma and is also known as IA-1. The protein functions primarily as a transcriptional regulator and contributes to gene expression programs involved in neuroendocrine lineage specification, cellular differentiation, and hormone-producing cell maturation.
During embryonic development, INSM1 is expressed in progenitor populations that give rise to multiple endocrine and neuronal cell types. It contributes to the differentiation of pancreatic endocrine cells, gastrointestinal neuroendocrine cells, and neural lineages. INSM1 is predominantly localized to the nucleus, consistent with its function as a DNA-binding transcription factor. Its expression becomes more restricted in many mature tissues, where it is associated primarily with specialized endocrine and neuroendocrine cell populations.
INSM1 has become an important marker in neuroendocrine tumor research because its expression is retained in numerous neoplasms exhibiting neuroendocrine differentiation. These include small cell lung carcinoma, pulmonary neuroendocrine tumors, Merkel cell carcinoma, pancreatic neuroendocrine tumors, and other neuroendocrine neoplasms. Investigation of INSM1 can therefore provide information about neuroendocrine lineage identity while also supporting studies of the transcriptional mechanisms involved in tumor development and differentiation.
Clone INSM1/6286R is a recombinant rabbit monoclonal antibody generated against a region within amino acids 81-125 of human INSM1. This IA-1 Monoclonal Antibody provides a defined monoclonal reagent for investigating the nuclear transcription factor and its association with endocrine and neuroendocrine differentiation. NSJ Bioreagents supplies clone INSM1/6286R for research use only.
An INSM1 Antibody can be used to investigate neuroendocrine differentiation, endocrine cell development, transcriptional regulation, and the biology of neuroendocrine tumors.
Explore our Cancer Marker Antibodies page for additional antibodies targeting proteins associated with tumor classification, differentiation, and cancer biology.
Optimal dilution of the INSM1 Antibody INSM1/6286R / IA-1 Monoclonal Antibody should be determined by the researcher.
A portion of amino acids 81-125 was used as the immunogen for the recombinant INSM1 Antibody INSM1/6286R.
Aliquot the INSM1 Antibody INSM1/6286R and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Insulinoma associated protein 1 antibody, IA-1 antibody, Zinc finger protein INSM1 antibody, Insulinoma associated transcription factor 1 antibody
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