- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
INHA Antibody Rabbit Monoclonal / Inhibin alpha INHA Antibody [clone INHA/6598R] (V9156)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9156-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9156-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9156SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | INHA/6598R |
| Purity | Protein A/G affinity |
| UniProt | P05111 |
| Localization | Cytoplasm, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant INHA antibody is available for research use only. |
|
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Inhibin subunit alpha (INHA) is a secreted glycoprotein hormone component encoded by the INHA gene and produced primarily by granulosa cells of the ovary and Sertoli cells of the testis. The protein is widely referred to as Inhibin alpha and forms part of the heterodimeric hormones inhibin A and inhibin B. INHA Antibody Rabbit Monoclonal (clone INHA/6598R) recognizes the INHA protein and enables detection of inhibin alpha expression in studies examining reproductive biology and endocrine related tumors.
Inhibins belong to the transforming growth factor beta (TGF beta) superfamily of signaling molecules. The inhibin alpha subunit associates with either the beta A or beta B subunit to form inhibin A or inhibin B respectively. These hormones function as endocrine regulators that suppress secretion of follicle stimulating hormone (FSH) from the anterior pituitary gland, thereby playing an important role in regulating gonadal endocrine signaling and reproductive physiology.
In normal tissues, INHA expression is most prominent in ovarian granulosa cells and testicular Sertoli cells. The protein is synthesized as a precursor that undergoes proteolytic processing before secretion. Through its endocrine activity, inhibin alpha participates in the feedback regulation of reproductive hormone signaling and contributes to control of follicular development and spermatogenesis.
Expression of inhibin alpha has also been documented in several tumor types derived from steroidogenic or sex cord stromal cell lineages. INHA expression has been reported in ovarian granulosa cell tumors, other sex cord stromal tumors, and certain adrenal cortical tumors. Detection of inhibin alpha protein therefore supports research examining endocrine tumor biology and the differentiation of steroid producing tissues.
INHA Antibody Rabbit Monoclonal (clone INHA/6598R) provides a reagent for detecting INHA protein in studies investigating gonadal development, reproductive hormone signaling, and endocrine tumor biology. Monoclonal antibodies recognize a defined epitope within the target antigen, enabling consistent antigen recognition and supporting investigation of inhibin alpha expression in molecular and cellular research systems.
Optimal dilution of the INHA Antibody Rabbit Monoclonal antibody should be determined by the researcher.
A portion of amino acids 233-362 was used as the immunogen for the recombinant INHA antibody.
Aliquot the recombinant INHA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Inhibin alpha antibody, Inhibin alpha subunit antibody, Inhibin A alpha antibody, Gonadal inhibin alpha antibody
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