- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
IL3RA Antibody / Interleukin 3 Receptor alpha / CD123 [clone rIL3RA/9212] (V5529)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5529-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5529-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5529SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rIL3RA/9212 |
| Purity | Protein A/G affinity |
| UniProt | P26951 |
| Localization | Cytoplasm, Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant IL3RA antibody is available for research use only. |
|
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IL3RA antibody targets Interleukin 3 receptor alpha, a type I transmembrane glycoprotein encoded by the IL3RA gene. Interleukin 3 receptor alpha is also commonly referred to as CD123 and represents the ligand-binding subunit of the interleukin-3 receptor complex. This receptor complex is formed through association with the shared beta chain, which is required for downstream signal transduction following cytokine engagement. IL3RA is predominantly localized to the cell surface, consistent with its role in mediating extracellular cytokine-dependent signaling events.
Interleukin 3 receptor alpha plays an essential role in hematopoietic regulation by supporting the survival, proliferation, and differentiation of progenitor and mature immune cells. CD123 antibody detection is widely used in studies examining myeloid lineage commitment, cytokine responsiveness, and immune cell homeostasis. IL3RA expression is most prominent on hematopoietic stem and progenitor cells, monocytes, basophils, plasmacytoid dendritic cells, and select lymphoid populations, making it a valuable marker for immune profiling and cellular phenotyping across multiple experimental systems.
Dysregulation of IL3RA expression has been reported in a range of hematologic malignancies, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, and other myeloproliferative disorders, where elevated CD123 expression is frequently observed on malignant blast populations. As a result, Interleukin 3 receptor alpha antibody reagents are commonly applied in research investigating disease-associated alterations in cytokine receptor signaling, leukemic cell biology, and immune cell differentiation pathways.
At the molecular level, IL3RA-mediated signaling contributes to activation of intracellular pathways involved in cell survival, proliferation, and differentiation, including signaling casc downstream of cytokine receptor engagement. These signaling events reinforce the importance of Interleukin 3 receptor alpha in maintaining normal immune system function and hematopoietic balance. This IL3RA antibody is designed to recognize Interleukin 3 receptor alpha, also known as CD123, in research applications and supports experimental studies focused on immune signaling mechanisms, hematopoiesis, and cytokine receptor expression dynamics.
Optimal dilution of the recombinant IL3RA antibody should be determined by the researcher.
A recombinant fragment of human IL3RA protein (within amino acids 26-171) was used as the immunogen for the recombinant IL3RA antibody.
Aliquot the recombinant IL3RA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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