- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant IL3RA Antibody / CD123 [clone CDLA123-1R] (V7468)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7468-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V7468-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7468SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7468IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CDLA123-1R |
| Purity | Protein A affinity chromatography |
| UniProt | P26951 |
| Localization | Cell surface, Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 0.25-0.5ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This recombinant IL3RA/CD123 antibody is available for research use only. |
|
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Recombinant IL3RA antibody targets Interleukin 3 receptor alpha, a cell surface cytokine receptor subunit encoded by the IL3RA gene and commonly referred to as CD123. Interleukin 3 receptor alpha serves as the primary ligand-binding component of the interleukin-3 receptor complex and is predominantly localized to the plasma membrane. Association with the shared beta chain enables signal transduction following cytokine engagement, linking IL3RA expression directly to regulation of hematopoietic and immune cell function.
Interleukin 3 receptor alpha is expressed across a range of hematopoietic cell types and displays dynamic regulation during immune development and activation. CD123 expression is detectable on hematopoietic stem and progenitor cells, monocytes, basophils, plasmacytoid dendritic cells, and select lymphoid populations. Because of this expression pattern, a recombinant IL3RA antibody is frequently used in studies examining immune cell differentiation, cytokine responsiveness, and lineage specification within the hematopoietic system.
IL3RA-mediated signaling supports key cellular processes including survival, proliferation, and functional maturation. Engagement of interleukin-3 with its receptor complex activates downstream pathways that influence cell fate decisions and immune cell expansion. Alterations in IL3RA expression levels have been linked to aberrant cytokine signaling and dysregulated immune responses, underscoring the importance of accurate IL3RA detection in experimental research.
Elevated expression of Interleukin 3 receptor alpha has been reported in multiple hematologic malignancies, where CD123 is often enriched on malignant cell populations compared with normal counterparts. As a result, recombinant IL3RA antibody reagents are widely applied in research investigating disease-associated changes in cytokine receptor expression, leukemic cell biology, and immune microenvironment interactions.
This recombinant IL3RA antibody is produced through controlled expression systems to ensure consistent antibody composition and performance across research applications. Clone CDLA123-1R is designed to recognize Interleukin 3 receptor alpha / CD123 and supports studies focused on immune signaling, hematopoiesis, and cytokine receptor biology. NSJ Bioreagents offers this recombinant IL3RA antibody for research use in immune and hematologic studies.
The stated application concentrations are suggested starting points. Titration of the recombinant IL3RA/CD123 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A portion of amino acids 26-171 was used as the immunogen for the recombinant IL3RA/CD123 antibody.
Store the recombinant IL3RA/CD123 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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