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Home >> Antibodies >> Recombinant IgA Heavy Chain Antibody

Recombinant IgA Heavy Chain Antibody [clone rHISA43] (V7859)

  Catalog No Formulation Size Price (USD)  
Image V7859-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 459
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V7859-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 209
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V7859SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 459
IHC staining of FFPE human tonsil with human recombinant IgA Heavy Chain antibody (clone rHISA43). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant IgA Heavy Chain antibody (clone rHISA43) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rHISA43
Purity Protein G affinity chromatography
UniProt P01876
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant IgA Heavy Chain antibody is available for research use only.
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Description

This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkins lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Application Notes

Optimal dilution of the recombinant IgA Heavy Chain antibody should be determined by the researcher.

Immunogen

Full length recombinant human IGHA protein was used as the immunogen for the human recombinant IgA Heavy Chain antibody.

Storage

Store the recombinant IgA Heavy Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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