- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant IgA Antibody / Heavy chain [clone IGHA/7567R] (V4381)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4381-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
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V4381-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V4381SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | IGHA/7567R |
| Purity | Protein A/G affinity |
| UniProt | P01876 , P01877 |
| Localization | Cytoplasm, Cell surface, Secreted |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant IgA antibody is available for research use only. |
|
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Recombinant IgA antibody detects the immunoglobulin A heavy chain, a core structural component of IgA antibodies responsible for mediating mucosal immune defense. The UniProt recommended name is Immunoglobulin heavy constant alpha (IGHA1/IGHA2, depending on subclass). IgA is the most abundant antibody isotype found in mucosal secretions such as saliva, tears, intestinal fluid, and respiratory mucus, where it serves as a first line of defense against pathogens at epithelial barriers.
Functionally, recombinant IgA antibody recognizes the alpha heavy chain that defines the IgA isotype. IgA exists in two major subclasses, IgA1 and IgA2, which differ in their hinge region and tissue distribution. Secretory IgA typically forms dimers or polymers through association with the J chain and the secretory component, allowing it to cross epithelial surfaces. This structure enables IgA to neutralize bacteria, viruses, and toxins without triggering strong inflammatory responses. In serum, monomeric IgA contributes to immune complex clearance via interaction with Fc alpha receptors on phagocytes.
The immunoglobulin alpha heavy chain gene is located on chromosome 14q32.33 and encodes the constant region that distinguishes IgA from other antibody classes. IgA is produced by plasma cells in mucosal tissues, tonsils, and Peyer's patches, and its secretion is regulated by cytokines such as TGF-beta and IL-10. Through engagement with polymeric immunoglobulin receptors (pIgR), IgA is transported across epithelial cells into mucosal secretions, forming secretory IgA that protects mucosal surfaces from infection.
Clinically, IgA serves as an important marker in immunological and pathological conditions. Elevated serum IgA levels can occur in chronic infections, autoimmune diseases, and liver disorders, while IgA deficiency is among the most common primary immunodeficiencies, predisposing individuals to respiratory and gastrointestinal infections. Abnormal deposition of IgA-containing immune complexes is characteristic of IgA nephropathy, a leading cause of glomerulonephritis worldwide.
Recombinant IgA antibody is validated for use in relevant immunological research applications to detect alpha heavy chain expression, quantify IgA levels, and study mucosal immunity. NSJ Bioreagents provides recombinant IgA antibody reagents optimized for immunology, diagnostics, and antibody structure-function research.
Optimal dilution of the recombinant IgA antibody should be determined by the researcher.
Full-length native purified protein corresponding to Human IgA was used as the immunogen for the recombinant IgA antibody. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain.
Aliquot the recombinant IgA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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