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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Human IgA Antibody for ELISA / Anti-IgA Detection Antibody [clone RM128] (R20182)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R20182-100UG | 1 mg/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | RM128 |
| Purity | Protein A purified from animal origin-free supernatant |
| UniProt | P01876 , P01877 |
| Gene ID | 3493 , 3494 |
| Applications | ELISA : 50ng/well-200ng/well (Capture); 0.05-0.2ug/ml (Detection) Immunohistochemistry : 0.1-1ug/ml |
| Limitations | This Human IgA Antibody for ELISA / Anti-IgA Detection Antibody is available for research use only. |
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Human immunoglobulin alpha (IGHA) encodes the heavy chain constant regions of IgA, an immunoglobulin class that plays a central role in mucosal immunity and immune protection at epithelial surfaces. IgA is the second most abundant immunoglobulin in circulation but is the dominant antibody isotype in mucosal secretions, where it exists primarily as dimeric secretory IgA associated with a joining chain and secretory component. This specialized structure enables IgA to function at barrier sites such as the gastrointestinal, respiratory, and genitourinary tracts, where it neutralizes pathogens and limits microbial adherence without triggering excessive inflammation.
Human IgA Antibody for ELISA / Anti-IgA Detection Antibody is specifically optimized for sensitive and selective detection of total IgA in ELISA-based immunoassays. Human IgA antibody, also known as anti-IGHA antibody or IgA immunoglobulin antibody, enables accurate quantification of IgA in serum, plasma, and mucosal samples including saliva and other secretions. This recombinant rabbit monoclonal antibody clone RM128 recognizes human IgA and provides a reliable tool for measuring IgA across diverse biological matrices.
In ELISA workflows, IgA detection presents unique challenges due to its presence in both monomeric serum forms and dimeric secretory forms in mucosal samples. The Human IgA Antibody for ELISA / Anti-IgA Detection Antibody functions effectively across these contexts, supporting consistent signal generation and accurate quantification in complex sample types. This is particularly important in studies of mucosal immunity, infection, and immune regulation, where IgA serves as a primary mediator of pathogen neutralization at barrier surfaces.
Clone RM128 antibody recognizes human IgA, supporting detection of total IgA while maintaining specificity against other immunoglobulin classes such as IgG, IgM, IgD, and IgE. The recombinant rabbit monoclonal format provides high affinity binding, strong reproducibility, and minimal lot-to-lot variability, ensuring consistent ELISA performance. This antibody is well suited for applications requiring reliable detection of IgA in both systemic and mucosal immune compartments.
Detection of IgA is widely applied in immunology research, infectious disease studies, and mucosal immune monitoring. Because IgA plays a critical role in barrier defense and early immune exclusion of pathogens, accurate measurement provides insight into immune status, infection dynamics, and host-pathogen interactions. This antibody supports these applications by enabling sensitive and specific detection of IGHA-containing immunoglobulins in ELISA-based systems requiring high performance, reproducibility, and quantitative accuracy.
This antibody is part of a broader immunoglobulin detection antibody collection, including reagents for Ig classes and light chains across multiple species and immunoassay formats.
The stated application concentrations are suggested starting points. Titration of the Human IgA Antibody for ELISA / Anti-IgA Detection Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Human IgA was used as the immunogen for this recombinant Human IgA antibody.
Store the recombinant Human IgA antibody at -20oC (with glycerol) or aliquot and store at -20oC (without glycerol).
Anti-IgA ELISA antibody, IGHA detection antibody, Human IgA detection antibody, IgA immunoglobulin antibody, pan-IgA antibody
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