- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HSV1 Antibody Recombinant Rabbit MAb / Herpes Simplex Virus Type I [clone HSV1/4055R] (V8925)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8925-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V8925-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V8925SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | HSV1 (Herpes Simplex Virus 1) |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | HSV1/4055R |
| Purity | Protein A affinity |
| Localization | Cytoplasmic, Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This HSV1 antibody is available for research use only. |
|
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HSV1 antibody recombinant rabbit mAb recognizes Herpes simplex virus type 1, an enveloped double stranded DNA virus classified within the Alphaherpesvirinae subfamily of the Herpesviridae family. HSV1 antibody, also referred to as Herpes simplex virus 1 antibody and HSV-1 antibody in the literature, detects viral antigens expressed during active infection and viral reactivation. This recombinant rabbit monoclonal antibody provides defined, high-affinity detection of HSV-1 proteins in infected cells and tissues.
Herpes simplex virus type 1 primarily infects epithelial cells of the oral and facial mucosa and subsequently establishes lifelong latency in sensory neurons, particularly within the trigeminal ganglia. During lytic infection, HSV-1 expresses immediate early, early, and late proteins that regulate viral transcription, genome replication, and virion assembly. Reactivation from latency leads to renewed viral protein synthesis and anterograde transport back to peripheral tissues, producing recurrent lesions. Detection of HSV-1 antigen expression is therefore essential for studying viral replication, latency, and reactivation models.
The HSV-1 genome encodes numerous structural and regulatory proteins, including envelope glycoproteins such as gB, gC, gD, and gE, as well as transcriptional regulators that localize primarily to the nucleus during replication. Viral antigens may exhibit nuclear, cytoplasmic, or membranous distribution depending on the stage of infection. Clone HSV1/4055R recognizes HSV-1 antigens and supports consistent monoclonal detection of viral protein expression in research settings.
HSV-1 infection is associated with orolabial lesions, keratitis, encephalitis, and increased risk of severe disease in immunocompromised individuals. In laboratory systems, HSV-1 is widely used to investigate viral latency, neuronal tropism, immune evasion mechanisms, and antiviral therapeutic development. A recombinant rabbit monoclonal format offers defined specificity and lot-to-lot consistency, supporting reproducible experimental design.
HSV1 antibody recombinant rabbit mAb (clone HSV1/4055R) is suitable for research applications focused on viral detection, host-pathogen interactions, and molecular analysis of Herpes simplex virus type 1 biology.
Optimal dilution of the HSV1 antibody should be determined by the researcher.
Detergent-solubilized herpes simplex virus (HSV) type 1 infected cells were used as the immunogen for the HSV1 antibody.
Aliquot the HSV1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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