- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant HLA-DQ Antibody rSPV-L3 / MHC Class II Antibody [clone rSPV-L3] (V7843)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7843-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V7843-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V7843SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rSPV-L3 |
| Purity | Protein G affinity chromatography |
| UniProt | P01908 , P01909 , P01920 |
| Localization | Cell surface |
| Applications | Flow Cytometry : 1-2ug/10^6 cells in 0.1ml Immunofluorescence : 1-2ug/ml |
| Limitations | This Recombinant HLA-DQ Antibody rSPV-L3 / MHC Class II Antibody is available for research use only. |
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Recombinant HLA-DQ Antibody rSPV-L3 / MHC Class II Antibody recognizes human HLA-DQ, a classical major histocompatibility complex (MHC) class II molecule involved in antigen presentation and adaptive immune recognition. HLA-DQ displays processed antigenic peptides at the cell surface for recognition by CD4-positive T lymphocytes. Interaction of peptide-loaded HLA-DQ with an appropriate T cell receptor can promote helper T cell activation and contribute to the coordination of downstream cellular and humoral immune responses.
HLA-DQ is a heterodimer composed of non-covalently associated alpha and beta chains, principally encoded by HLA-DQA1 and HLA-DQB1. Both chains contribute to the extracellular peptide-binding groove and contain polymorphic residues that influence peptide-binding specificity. Extensive genetic variation within the HLA-DQ system produces considerable diversity in antigen presentation among individuals and contributes to associations between particular HLA-DQ alleles and susceptibility to autoimmune and immune-mediated diseases.
HLA-DQ expression is characteristic of professional antigen-presenting cells, including B lymphocytes, dendritic cells and macrophages. Proteins internalized by these cells can be processed within endosomal compartments, where resulting peptides are loaded onto MHC class II molecules. Peptide-HLA-DQ complexes are subsequently transported to the plasma membrane for recognition by CD4-positive T cells. Expression of HLA-DQ can also be influenced by cellular activation and inflammatory signaling.
A Recombinant HLA-DQ Antibody provides a defined monoclonal reagent for investigating HLA-DQ within the broader MHC class II system. HLA-DQ-directed antibodies complement reagents recognizing HLA-DP, HLA-DR or shared pan-HLA class II determinants and can help distinguish DQ-associated expression from broader class II expression. HLA-DQ biology is particularly relevant to studies of antigen presentation, immunogenetics, autoimmunity, transplantation, infectious disease and adaptive immune regulation.
Clone rSPV-L3 is a recombinant mouse monoclonal antibody characterized for recognition of human HLA-DQ. The T4-positive cytotoxic T lymphocyte clone HG-38 was used as the immunogen, and the antibody has been characterized as strongly blocking cytotoxic activity of T4-positive cytotoxic T cell clones. NSJ Bioreagents provides this Recombinant HLA-DQ Antibody for research into MHC class II biology, antigen presentation and immune-cell recognition. An MHC Class II Antibody targeting HLA-DQ can support investigation of HLA-DQ-mediated adaptive immune responses.
For additional information on HLA-DQ biology and complementary antibody validation, visit our HLA-DQ Antibody SPV-L3 / MHC Class II Antibody page.
Optimal dilution of the Recombinant HLA-DQ Antibody rSPV-L3 / MHC Class II Antibody should be determined by the researcher.
The T4-positive CTL clone HG-38 was used as the immunogen for the Recombinant HLA-DQ Antibody rSPV-L3.
Store the Recombinant HLA-DQ Antibody rSPV-L3 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Recombinant HLA-DQ antibody, HLA-DQ antibody, MHC Class II antibody, HLA Class II DQ antibody, rSPV-L3 antibody
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