- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
HBA Antibody rHBA/9167 / Alpha-Globin Antibody [clone rHBA/9167] (V5570)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5570-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5570-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5570SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rHBA/9167 |
| Purity | Protein A/G affinity |
| UniProt | P69905 |
| Localization | Extracellular space |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This HBA Antibody rHBA/9167 / Alpha-Globin Antibody is available for research use only. |
|
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HBA Antibody rHBA/9167 / Alpha-Globin Antibody recognizes alpha-globin, one of the principal protein components of hemoglobin. In humans, alpha-globin is encoded by the closely related HBA1 and HBA2 genes located within the alpha-globin gene cluster on chromosome 16. The proteins encoded by these genes have identical amino acid sequences and associate with beta-like globin chains to form functional hemoglobin tetramers responsible for oxygen transport in erythrocytes.
Alpha-globin participates in several developmentally regulated forms of hemoglobin. In adults, it associates primarily with beta-globin to form hemoglobin A, the predominant form of circulating hemoglobin, and with delta-globin to form the minor HbA2 fraction. During fetal development, alpha-globin associates with gamma-globin to form fetal hemoglobin. Coordinated expression of these globin chains is an essential feature of normal erythroid differentiation and red blood cell function.
Balanced globin-chain synthesis is important for hemoglobin stability and erythrocyte development. Decreased alpha-globin production is associated with alpha-thalassemia, while accumulation of excess unpaired alpha-globin contributes to erythroid pathology in beta-thalassemia. Alpha-globin is consequently studied in research involving erythropoiesis, hemoglobin switching, red blood cell development and inherited hemoglobin disorders.
Clone rHBA/9167 is a recombinant mouse monoclonal antibody generated against a recombinant fragment from within amino acids 1-100 of human HBA2. Its recombinant production provides a defined monoclonal reagent for investigating alpha-globin expression. NSJ Bioreagents provides this HBA Antibody for research into erythroid biology, hemoglobin expression and red blood cell development. An Alpha-Globin Antibody can support studies of hemoglobin biology and erythroid differentiation.
For additional information on alpha-globin biology and broader tissue and species validation, visit our Hemoglobin Alpha Antibody / HBA1/2 Antibody page.
Optimal dilution of the HBA Antibody rHBA/9167 / Alpha-Globin Antibody should be determined by the researcher.
A recombinant fragment (within amino acids 1-100) of human HBA2 protein was used as the immunogen for the recombinant HBA Antibody rHBA/9167.
Aliquot the HBA Antibody rHBA/9167 and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
HBA antibody, alpha-globin antibody, hemoglobin alpha chain antibody, hemoglobin subunit alpha antibody, HBA1 antibody, HBA2 antibody
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