- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
H3K23me2 Antibody / HIST1H3A Chromatin Remodeling Integration Antibody [clone RM171] (R20219)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R20219-100UG | 1 mg/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide | 100 ug | 485 | |
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R20219-25UG | 1 mg/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide | 25 ug | 259 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | RM171 |
| Purity | Protein A purified from animal origin-free supernatant |
| UniProt | P84243 |
| Gene ID | 8350 |
| Applications | Western Blot : 0.5-2ug/ml ELISA : 0.1ug/ml-0.5ug/ml |
| Limitations | This H3K23me2 antibody is available for research use only. |
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Histone H3 (HIST1H3A) methylation at lysine 23 represents a regulatory chromatin modification associated with chromatin remodeling and integration of epigenetic signals across gene regulatory regions. H3K23me2 Antibody / HIST1H3A Chromatin Remodeling Integration Antibody (clone RM171) is designed to detect Histone H3 dimethylated at lysine 23, providing a marker of chromatin states that coordinate multiple regulatory inputs to control gene expression. This antibody is part of a broader collection of Histone H3 antibodies used to study chromatin structure, histone modifications, and epigenetic regulation.
HIST1H3A antibody, also referred to as Histone H3 antibody and H3K23me2 antibody in the literature, recognizes a modification located within the N-terminal tail of histone H3 that participates in combinatorial epigenetic regulation. In contrast to H3K23ac, which is associated with transcriptional activation, H3K23me2 reflects chromatin environments involved in regulatory coordination and signal integration rather than direct transcriptional output.
This recombinant rabbit monoclonal clone RM171 antibody is uniquely positioned for studies of chromatin remodeling and epigenetic integration. H3K23 dimethylation is often present in genomic regions where activating and repressive signals converge, allowing cells to fine-tune gene expression in response to developmental cues and environmental stimuli.
At the molecular level, H3K23me2 contributes to chromatin states that facilitate recruitment of regulatory complexes and histone-modifying enzymes. It participates in combinatorial histone modification patterns that define chromatin accessibility, transcriptional responsiveness, and structural organization.
This modification frequently coexists with both activating and repressive marks, highlighting its role as an integrative component within complex chromatin landscapes. Its presence reflects coordinated regulation rather than discrete activation or silencing events.
In western blot applications, the antibody detects Histone H3 at approximately 15 kDa, with signal corresponding to dimethylated chromatin associated with regulatory integration and remodeling processes. Detection reflects coordinated chromatin control rather than promoter-specific or elongation-associated activity.
At the cellular level, H3K23 dimethylation localizes to the nucleus and is enriched in chromatin regions undergoing regulatory transitions. This supports its use in studying chromatin remodeling and epigenetic signal integration.
This antibody supports detection of Lys23-dimethylated Histone H3, enabling investigation of chromatin remodeling, epigenetic coordination, and integrated regulation of gene expression.
The stated application concentrations are suggested starting points. Titration of the H3K23me2 Antibody / HIST1H3A Chromatin Remodeling Integration Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A dimethyl-peptide corresponding to Dimethyl-Histone H3 (Lys23) was used as the immunogen for this H3K23me2 Antibody / HIST1H3A Chromatin Remodeling Integration Antibody.
Store the recombinant H3K23me2 antibody at -20oC (with glycerol) or aliquot and store at -20oC (without glycerol).
Histone H3 Lys23 dimethylation antibody, H3K23me2 chromatin remodeling antibody, histone H3 di methyl Lys23 antibody, H3K23 dimethyl histone antibody
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