- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
H2A.ZK7ac Antibody / H2AFZ Transcriptional Responsiveness Antibody [clone RM222] (R20240)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R20240-100UG | 1 mg/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide | 100 ug | 485 | |
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R20240-25UG | 1 mg/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide | 25 ug | 259 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | RM222 |
| Purity | Protein A purified from animal origin-free supernatant |
| UniProt | P0C0S5 |
| Gene ID | 3015 |
| Applications | Western Blot : 0.5-2ug/ml ELISA : 0.2-1ug/ml Immunocytochemistry : 1-2ug/ml |
| Limitations | This recombinant H2A.ZK7ac antibody is available for research use only. |
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Histone variant H2A.Z (H2AFZ) acetylation at lysine 7 is a regulatory chromatin modification associated with transcriptional responsiveness and dynamic gene regulation. H2A.ZK7ac Antibody / H2AFZ Transcriptional Responsiveness Antibody (clone RM222) is designed to detect H2A.Z acetylated at lysine 7, providing a marker of chromatin regions that respond rapidly to signaling pathways and environmental stimuli. Included within the Histone H2A antibodies collection, this antibody enables analysis of histone modification patterns and chromatin regulatory mechanisms involving H2A and its variants.
H2AFZ antibody, also referred to as H2A.Z antibody and H2A.ZK7ac antibody in the literature, recognizes a modification specific to the H2A.Z histone variant. H2A.Z is enriched at promoters and regulatory regions where it modulates nucleosome positioning and chromatin accessibility.
This recombinant rabbit monoclonal clone RM222 antibody is uniquely positioned for studies of inducible gene expression and transcriptional responsiveness. H2A.Z lysine 7 acetylation is associated with genes that are activated in response to cellular signaling events, including stress responses and developmental cues.
At the molecular level, acetylation of H2A.Z reduces nucleosome stability and enhances chromatin accessibility, allowing rapid recruitment of transcription factors and regulatory complexes. H2A.ZK7ac is frequently observed at inducible promoters and regulatory elements undergoing dynamic activation.
This modification contributes to flexible chromatin architecture and enables rapid transcriptional responses. Its presence reflects regulatory adaptability rather than stable activation or repression.
In western blot applications, the antibody detects H2A.Z at approximately 14 kDa, with signal corresponding to acetylated chromatin associated with transcriptional responsiveness. Detection reflects dynamic gene regulation rather than constitutive transcriptional activity.
At the cellular level, H2A.Z lysine 7 acetylation localizes to the nucleus and is enriched in regulatory chromatin regions. This supports its use in studying signal-dependent gene activation and chromatin remodeling.
This antibody supports detection of Lys7-acetylated H2A.Z, enabling investigation of transcriptional responsiveness, chromatin remodeling, and epigenetic regulation of gene expression.
The stated application concentrations are suggested starting points. Titration of the H2A.ZK7ac Antibody / H2AFZ Transcriptional Responsiveness Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An acetyl-peptide corresponding to Acetyl-Histone H2A.Z (Lys7) was used as the immunogen for this H2A.ZK7ac Antibody / H2AFZ Transcriptional Responsiveness Antibody.
Store the recombinant H2A.ZK7ac antibody at -20oC (with glycerol) or aliquot and store at -20oC (without glycerol).
H2A.Z Lys7 acetylation antibody, H2AFZ K7ac transcription antibody, acetyl H2A.Z Lys7 antibody, H2AZ K7 acetyl histone antibody
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