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Home >> Antibodies >> Recombinant GZMB Antibody / Granzyme B

Recombinant GZMB Antibody / Granzyme B [clone rGZMB/4538] (V9489)

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  Catalog No Formulation Size Price (USD)  
Image V9489-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9489-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9489SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538). Predicted molecular weight: 29-37 kDa.
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Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538). Predicted molecular weight: 29-37 kDa.
IHC staining of FFPE human tonsil tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human spleen tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant GZMB antibody (clone rGZMB/4538) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG2a, kappa
Clone Name rGZMB/4538
Purity Protein A/G affinity
UniProt P10144
Localization Cytoplasm
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant GZMB antibody is available for research use only.
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Description

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

Application Notes

Optimal dilution of the recombinant GZMB antibody should be determined by the researcher.

Immunogen

A portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.

Storage

Aliquot the recombinant GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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