- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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GST Mu 3 Antibody / Recombinant GSTM3 Antibody recognizes GSTM3, a cytosolic enzyme belonging to the mu class of glutathione S-transferases. GSTM3 contributes to cellular detoxification by catalyzing the conjugation of reduced glutathione to electrophilic compounds. This activity helps protect cells against reactive products generated by oxidative stress as well as environmental toxins, carcinogens and other xenobiotic compounds.
GSTM3 is one of several closely related mu class GST enzymes encoded within a gene cluster on chromosome 1. Members of this family participate in glutathione-dependent metabolism and cellular defense against potentially damaging chemical compounds. Mu class GST genes are polymorphic, and genetic variation can influence individual responses to environmental exposures and therapeutic agents. GSTM3 is therefore relevant to research involving toxicology, pharmacology, xenobiotic metabolism and oxidative stress.
GSTM3 has also been investigated in cancer biology, where changes in glutathione-dependent detoxification and antioxidant defense can influence cellular responses to carcinogens and oxidative damage. Altered GSTM3 expression and genetic variation have been studied in multiple malignancies. Reduced GSTM3 expression has received particular attention in renal cell carcinoma, where it has been associated with disease risk and clinical outcome. These observations connect GSTM3 biology with research into metabolic defense mechanisms, cellular stress and tumor development.
Clone rGSTM3/8878 is a recombinant mouse monoclonal antibody generated against full-length recombinant human GSTM3 and purified by Protein A/G affinity chromatography. NSJ Bioreagents provides this GST Mu 3 Antibody for research into glutathione-dependent metabolism, oxidative stress and GSTM3 biology. A Recombinant GSTM3 Antibody provides a defined monoclonal reagent for investigating this mu class detoxification enzyme.
For additional reagents and information on GSTM3-mediated detoxification and oxidative stress responses, visit our GSTM3 Antibody / Glutathione S-Transferase Mu 3 Antibody page.
Optimal dilution of the GST Mu 3 Antibody / Recombinant GSTM3 Antibody should be determined by the researcher.
Recombinant full-length human GSTM3 protein was used as the immunogen for the recombinant GSTM3 antibody.
Aliquot the recombinant GSTM3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
GST Mu 3 antibody, GSTM3 antibody, Glutathione S-Transferase Mu 3 antibody, recombinant GSTM3 antibody
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