- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Granzyme B Antibody [clone GZMB/4539R] (V9508)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
V9508-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 519 | |
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V9508-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 229 | |
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V9508SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | GZMB/4539R |
| Purity | Protein A/G affinity |
| UniProt | P10144 |
| Localization | Cytoplasm |
| Applications | Western blot : 2-4ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant Granzyme B antibody is available for research use only. |
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Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
Optimal dilution of the recombinant Granzyme B antibody should be determined by the researcher.
A portion of amino acids 73-187 was used as the immunogen for the recombinant Granzyme B antibody.
Aliquot the recombinant Granzyme B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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