- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GP2 Antibody Recombinant Rabbit MAb GP2/3134R / Glycoprotein 2 / ZAP75 [clone GP2/3134R] (V7415)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7415-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7415-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7415SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7415IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | GP2/3134R |
| Purity | Protein A affinity chromatography |
| UniProt | P55259 |
| Localization | Cytoplasmic, membranous, secreted |
| Applications | ELISA : 2-4ug/ml (order BSA/azide-free format) Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This GP2/Glycoprotein 2 antibody is available for research use only. |
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Glycoprotein 2 (GP2), encoded by the GP2 gene, is a secretory granule membrane protein most prominently expressed in pancreatic acinar cells. GP2 Antibody recognizes Glycoprotein 2, also referred to in the literature as pancreatic secretory granule membrane major glycoprotein GP2 and zymogen granule membrane glycoprotein 2. This glycosylated membrane protein is a major structural component of pancreatic zymogen granules and contributes to the specialized secretory machinery that supports digestive enzyme production in the exocrine pancreas.
GP2 is synthesized in pancreatic acinar cells and becomes integrated into the membranes of zymogen granules, which store digestive enzymes prior to secretion into the pancreatic ductal system. During enzyme secretion, these granules fuse with the apical plasma membrane, releasing digestive enzymes into the pancreatic ducts. Glycoprotein 2 can subsequently be shed from the granule membrane and released into the pancreatic lumen. Because of this biology, GP2 expression is highly characteristic of pancreatic acinar cells and is closely associated with the presence of mature secretory granules in the exocrine pancreas.
GP2 Antibody Recombinant Rabbit MAb GP2/3134R targets this acinar cell-associated protein for research applications examining pancreatic tissue organization and epithelial differentiation. In histologic specimens, Glycoprotein 2 is typically detected as cytoplasmic and apical staining within pancreatic acinar cells, corresponding to the localization of zymogen granules. This distribution pattern reflects the functional role of GP2 in secretory vesicle biology and helps distinguish acinar cell populations in tissue-based studies.
In addition to its well-established role in pancreatic secretion, GP2 has also been detected in certain epithelial and mucosal environments where it may participate in host-microbe interactions. Studies have shown that GP2 can bind to bacterial components and may function in mucosal immune recognition pathways, particularly in epithelial cells exposed to luminal microbes. These observations suggest that Glycoprotein 2 may contribute not only to digestive enzyme secretion but also to epithelial barrier biology and microbial sensing.
Recombinant Glycoprotein 2 antibody supports the detection of GP2 protein expression in studies of pancreatic physiology, epithelial cell differentiation, and secretory granule biology. Because GP2 expression strongly correlates with pancreatic acinar differentiation, analysis of Glycoprotein 2 expression is frequently used in research focused on pancreatic tissue organization, secretory cell function, and diseases involving the exocrine pancreas.
Optimal dilution of the GP2 antibody recombinant rabbit mAb GP2/3134R should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2/Glycoprotein 2 antibody.
Store the recombinant GP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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